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A Case of Hypokalemia Possibly Induced by Nafcillin
(1) Background: The use of intravenous antibiotics for severe infections is a common practice, either as inpatient or outpatient treatment. In the case of methicillin-susceptible Staphylococcus aureus (MSSA), nafcillin is a commonly prescribed intravenous antibiotic, given its known efficacy to trea...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315441/ https://www.ncbi.nlm.nih.gov/pubmed/30545049 http://dx.doi.org/10.3390/antibiotics7040108 |
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author | Casado, Fernando Mudunuru, Sitarama Arvind Nasr, Rabih |
author_facet | Casado, Fernando Mudunuru, Sitarama Arvind Nasr, Rabih |
author_sort | Casado, Fernando |
collection | PubMed |
description | (1) Background: The use of intravenous antibiotics for severe infections is a common practice, either as inpatient or outpatient treatment. In the case of methicillin-susceptible Staphylococcus aureus (MSSA), nafcillin is a commonly prescribed intravenous antibiotic, given its known efficacy to treat infections related to this organism effectively. However, it is not without side effects. (2) Methods: We present an interesting case of persistent hypokalemia in a patient after he was started on nafcillin infusion for an MSSA infection, which eventually resolved with the completion of the treatment. (3) Results: Hypokalemia is a known side effect of nafcillin infusion, and it is believed to be mainly due to its antibiotic effect as a non-absorbable ion in the distal tubule and/or intracellular redistribution due to volume depletion. (4) Conclusions: A review of the available literature revealed that hypokalemia is a known side effect of nafcillin infusion; however, if present, it is usually mild, and only a few cases of severe hypokalemia have been reported. Usually, hypokalemia resolves when the nafcillin infusion is stopped; however, in certain cases, when this is not possible, oral potassium replacement can be used while the patient is receiving nafcillin. Clinicians should be aware of this rare, but possible, complication when using nafcillin. |
format | Online Article Text |
id | pubmed-6315441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63154412019-01-11 A Case of Hypokalemia Possibly Induced by Nafcillin Casado, Fernando Mudunuru, Sitarama Arvind Nasr, Rabih Antibiotics (Basel) Case Report (1) Background: The use of intravenous antibiotics for severe infections is a common practice, either as inpatient or outpatient treatment. In the case of methicillin-susceptible Staphylococcus aureus (MSSA), nafcillin is a commonly prescribed intravenous antibiotic, given its known efficacy to treat infections related to this organism effectively. However, it is not without side effects. (2) Methods: We present an interesting case of persistent hypokalemia in a patient after he was started on nafcillin infusion for an MSSA infection, which eventually resolved with the completion of the treatment. (3) Results: Hypokalemia is a known side effect of nafcillin infusion, and it is believed to be mainly due to its antibiotic effect as a non-absorbable ion in the distal tubule and/or intracellular redistribution due to volume depletion. (4) Conclusions: A review of the available literature revealed that hypokalemia is a known side effect of nafcillin infusion; however, if present, it is usually mild, and only a few cases of severe hypokalemia have been reported. Usually, hypokalemia resolves when the nafcillin infusion is stopped; however, in certain cases, when this is not possible, oral potassium replacement can be used while the patient is receiving nafcillin. Clinicians should be aware of this rare, but possible, complication when using nafcillin. MDPI 2018-12-12 /pmc/articles/PMC6315441/ /pubmed/30545049 http://dx.doi.org/10.3390/antibiotics7040108 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Casado, Fernando Mudunuru, Sitarama Arvind Nasr, Rabih A Case of Hypokalemia Possibly Induced by Nafcillin |
title | A Case of Hypokalemia Possibly Induced by Nafcillin |
title_full | A Case of Hypokalemia Possibly Induced by Nafcillin |
title_fullStr | A Case of Hypokalemia Possibly Induced by Nafcillin |
title_full_unstemmed | A Case of Hypokalemia Possibly Induced by Nafcillin |
title_short | A Case of Hypokalemia Possibly Induced by Nafcillin |
title_sort | case of hypokalemia possibly induced by nafcillin |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315441/ https://www.ncbi.nlm.nih.gov/pubmed/30545049 http://dx.doi.org/10.3390/antibiotics7040108 |
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