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Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria

Polyhydroxyalkanoates (PHAs) are a group of biopolymers produced in various microorganisms as carbon and energy reserve when the main nutrient, necessary for growth, is limited. PHAs are attractive substitutes for conventional petrochemical plastics, as they possess similar material properties, alon...

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Autores principales: Kamravamanesh, Donya, Lackner, Maximilian, Herwig, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315491/
https://www.ncbi.nlm.nih.gov/pubmed/30567391
http://dx.doi.org/10.3390/bioengineering5040111
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author Kamravamanesh, Donya
Lackner, Maximilian
Herwig, Christoph
author_facet Kamravamanesh, Donya
Lackner, Maximilian
Herwig, Christoph
author_sort Kamravamanesh, Donya
collection PubMed
description Polyhydroxyalkanoates (PHAs) are a group of biopolymers produced in various microorganisms as carbon and energy reserve when the main nutrient, necessary for growth, is limited. PHAs are attractive substitutes for conventional petrochemical plastics, as they possess similar material properties, along with biocompatibility and complete biodegradability. The use of PHAs is restricted, mainly due to the high production costs associated with the carbon source used for bacterial fermentation. Cyanobacteria can accumulate PHAs under photoautotrophic growth conditions using CO(2) and sunlight. However, the productivity of photoautotrophic PHA production from cyanobacteria is much lower than in the case of heterotrophic bacteria. Great effort has been focused to reduce the cost of PHA production, mainly by the development of optimized strains and more efficient cultivation and recovery processes. Minimization of the PHA production cost can only be achieved by considering the design and a complete analysis of the whole process. With the aim on commercializing PHA, this review will discuss the advances and the challenges associated with the upstream processing of cyanobacterial PHA production, in order to help the design of the most efficient method on the industrial scale.
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spelling pubmed-63154912019-01-10 Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria Kamravamanesh, Donya Lackner, Maximilian Herwig, Christoph Bioengineering (Basel) Review Polyhydroxyalkanoates (PHAs) are a group of biopolymers produced in various microorganisms as carbon and energy reserve when the main nutrient, necessary for growth, is limited. PHAs are attractive substitutes for conventional petrochemical plastics, as they possess similar material properties, along with biocompatibility and complete biodegradability. The use of PHAs is restricted, mainly due to the high production costs associated with the carbon source used for bacterial fermentation. Cyanobacteria can accumulate PHAs under photoautotrophic growth conditions using CO(2) and sunlight. However, the productivity of photoautotrophic PHA production from cyanobacteria is much lower than in the case of heterotrophic bacteria. Great effort has been focused to reduce the cost of PHA production, mainly by the development of optimized strains and more efficient cultivation and recovery processes. Minimization of the PHA production cost can only be achieved by considering the design and a complete analysis of the whole process. With the aim on commercializing PHA, this review will discuss the advances and the challenges associated with the upstream processing of cyanobacterial PHA production, in order to help the design of the most efficient method on the industrial scale. MDPI 2018-12-18 /pmc/articles/PMC6315491/ /pubmed/30567391 http://dx.doi.org/10.3390/bioengineering5040111 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kamravamanesh, Donya
Lackner, Maximilian
Herwig, Christoph
Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria
title Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria
title_full Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria
title_fullStr Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria
title_full_unstemmed Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria
title_short Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria
title_sort bioprocess engineering aspects of sustainable polyhydroxyalkanoate production in cyanobacteria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315491/
https://www.ncbi.nlm.nih.gov/pubmed/30567391
http://dx.doi.org/10.3390/bioengineering5040111
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