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Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care

Background: Sarcopenia is a widespread concern in chronic kidney disease (CKD) as well in elderly patients and is one of the main reasons why low-protein diets for this population are controversial. The aim of this study was to assess the prevalence and correlates of sarcopenia among elderly male pa...

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Autores principales: D’Alessandro, Claudia, Piccoli, Giorgina Barbara, Barsotti, Massimiliano, Tassi, Serena, Giannese, Domenico, Morganti, Riccardo, Cupisti, Adamasco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315502/
https://www.ncbi.nlm.nih.gov/pubmed/30544657
http://dx.doi.org/10.3390/nu10121951
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author D’Alessandro, Claudia
Piccoli, Giorgina Barbara
Barsotti, Massimiliano
Tassi, Serena
Giannese, Domenico
Morganti, Riccardo
Cupisti, Adamasco
author_facet D’Alessandro, Claudia
Piccoli, Giorgina Barbara
Barsotti, Massimiliano
Tassi, Serena
Giannese, Domenico
Morganti, Riccardo
Cupisti, Adamasco
author_sort D’Alessandro, Claudia
collection PubMed
description Background: Sarcopenia is a widespread concern in chronic kidney disease (CKD) as well in elderly patients and is one of the main reasons why low-protein diets for this population are controversial. The aim of this study was to assess the prevalence and correlates of sarcopenia among elderly male patients affected by CKD followed up in an outpatient nephrology clinic, where moderate protein restriction (0.6–0.8 g/Kg/day) is routinely recommended to patients in CKD stage 3b-5 not on dialysis. Methods: This observational study included 80 clinically-stable male out-patients aged >60, affected by stage 3b-4 CKD. Forty patients aged ≥75 (older seniors) were compared to the other forty patients aged 60–74 (younger seniors). All patients underwent a comprehensive nutritional and functional assessment. Results: Older seniors showed lower serum albumin, hand-grip strength, body mass index (BMI), skeletal muscle mass, and resting energy expenditure. Protein intake was significantly lower in older seniors whereas energy intake was similar. Average daily physical activity was lower in the older seniors than in the younger ones. Sarcopenia was more prevalent in older than in younger seniors. Among older seniors, sarcopenic and non-sarcopenic ones differed in age and performance on the Six-Minute Walk test, whereas the estimated glomerular filtration rate (eGFR), biochemistry, dietary protein, and energy intakes were similar. Conclusions: Older senior CKD male patients have lower muscle mass, muscle strength, and physical capacity and activity levels, with a higher prevalence of sarcopenia than younger patients. This occurs at the same residual renal function and metabolic profile and protein intake. Energy intake was at the target in both subgroups. In this CKD cohort, sarcopenia was associated with age and physical capacity, but not with eGFR or dietary intakes.
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spelling pubmed-63155022019-01-08 Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care D’Alessandro, Claudia Piccoli, Giorgina Barbara Barsotti, Massimiliano Tassi, Serena Giannese, Domenico Morganti, Riccardo Cupisti, Adamasco Nutrients Article Background: Sarcopenia is a widespread concern in chronic kidney disease (CKD) as well in elderly patients and is one of the main reasons why low-protein diets for this population are controversial. The aim of this study was to assess the prevalence and correlates of sarcopenia among elderly male patients affected by CKD followed up in an outpatient nephrology clinic, where moderate protein restriction (0.6–0.8 g/Kg/day) is routinely recommended to patients in CKD stage 3b-5 not on dialysis. Methods: This observational study included 80 clinically-stable male out-patients aged >60, affected by stage 3b-4 CKD. Forty patients aged ≥75 (older seniors) were compared to the other forty patients aged 60–74 (younger seniors). All patients underwent a comprehensive nutritional and functional assessment. Results: Older seniors showed lower serum albumin, hand-grip strength, body mass index (BMI), skeletal muscle mass, and resting energy expenditure. Protein intake was significantly lower in older seniors whereas energy intake was similar. Average daily physical activity was lower in the older seniors than in the younger ones. Sarcopenia was more prevalent in older than in younger seniors. Among older seniors, sarcopenic and non-sarcopenic ones differed in age and performance on the Six-Minute Walk test, whereas the estimated glomerular filtration rate (eGFR), biochemistry, dietary protein, and energy intakes were similar. Conclusions: Older senior CKD male patients have lower muscle mass, muscle strength, and physical capacity and activity levels, with a higher prevalence of sarcopenia than younger patients. This occurs at the same residual renal function and metabolic profile and protein intake. Energy intake was at the target in both subgroups. In this CKD cohort, sarcopenia was associated with age and physical capacity, but not with eGFR or dietary intakes. MDPI 2018-12-10 /pmc/articles/PMC6315502/ /pubmed/30544657 http://dx.doi.org/10.3390/nu10121951 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
D’Alessandro, Claudia
Piccoli, Giorgina Barbara
Barsotti, Massimiliano
Tassi, Serena
Giannese, Domenico
Morganti, Riccardo
Cupisti, Adamasco
Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care
title Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care
title_full Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care
title_fullStr Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care
title_full_unstemmed Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care
title_short Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care
title_sort prevalence and correlates of sarcopenia among elderly ckd outpatients on tertiary care
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315502/
https://www.ncbi.nlm.nih.gov/pubmed/30544657
http://dx.doi.org/10.3390/nu10121951
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