Cargando…

Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the “Test of Time”

Human Cytomegalovirus (hCMV), which is the prototype member of the β-subfamily of the herpesvirus family, is a pathogen of high clinical relevance in recipients of hematopoietic cell transplantation (HCT). hCMV causes multiple-organ disease and interstitial pneumonia in particular upon infection dur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reddehase, Matthias J., Lemmermann, Niels A. W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315540/ https://www.ncbi.nlm.nih.gov/pubmed/30563202 http://dx.doi.org/10.3390/v10120693

Ejemplares similares

Host-Adapted Gene Families Involved in Murine Cytomegalovirus Immune Evasion
por: Becker, Sara, et al.
Publicado: (2022)

Direct Evidence for Viral Antigen Presentation during Latent Cytomegalovirus Infection
por: Lemmermann, Niels A. W., et al.
Publicado: (2021)

Mast Cells Meet Cytomegalovirus: A New Example of Protective Mast Cell Involvement in an Infectious Disease
por: Becker, Sara, et al.
Publicado: (2022)

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance
por: Holtappels, Rafaela, et al.
Publicado: (2016)

Consequence of Histoincompatibility beyond GvH-Reaction in Cytomegalovirus Disease Associated with Allogeneic Hematopoietic Cell Transplantation: Change of Paradigm
por: Reddehase, Matthias J., et al.
Publicado: (2021)

The p36 Isoform of Murine Cytomegalovirus m152 Protein Suffices for Mediating Innate and Adaptive Immune Evasion
por: Fink, Annette, et al.
Publicado: (2013)

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells
por: Holtappels, Rafaela, et al.
Publicado: (2023)

Localization of Viral Epitope-Specific CD8 T Cells during Cytomegalovirus Latency in the Lungs and Recruitment to Lung Parenchyma by Airway Challenge Infection
por: Blaum, Franziska, et al.
Publicado: (2021)

Memory CD8 T Cells Protect against Cytomegalovirus Disease by Formation of Nodular Inflammatory Foci Preventing Intra-Tissue Virus Spread
por: Holtappels, Rafaela, et al.
Publicado: (2022)

Cytomegalovirus-Associated Inhibition of Hematopoiesis Is Preventable by Cytoimmunotherapy With Antiviral CD8 T Cells
por: Renzaho, Angelique, et al.
Publicado: (2020)

Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection
por: Gergely, Kerstin M., et al.
Publicado: (2021)

Cytomegalovirus pneumonitis in an immunocompromised host
por: Balakrishnan, Rabitha, et al.
Publicado: (2022)

Revisiting CD8 T-cell ‘Memory Inflation’: New Insights with Implications for Cytomegaloviruses as Vaccine Vectors
por: Holtappels, Rafaela, et al.
Publicado: (2020)

The Anti-apoptotic Murine Cytomegalovirus Protein vMIA-m38.5 Induces Mast Cell Degranulation
por: Schmiedeke, Julia K., et al.
Publicado: (2020)

Stochastic Episodes of Latent Cytomegalovirus Transcription Drive CD8 T-Cell “Memory Inflation” and Avoid Immune Evasion
por: Griessl, Marion, et al.
Publicado: (2021)

Reverse Genetics Modification of Cytomegalovirus Antigenicity and Immunogenicity by CD8 T-Cell Epitope Deletion and Insertion
por: Lemmermann, Niels A. W., et al.
Publicado: (2011)

Pathogenesis of human cytomegalovirus in the immunocompromised host
por: Griffiths, Paul, et al.
Publicado: (2021)

Cytomegalovirus Hepatitis in Immunocompetent and Immunocompromised Hosts
por: Da Cunha, Teresa, et al.
Publicado: (2021)

Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
por: Lemmermann, Niels A. W., et al.
Publicado: (2015)

Noncanonical Expression of a Murine Cytomegalovirus Early Protein CD8 T-Cell Epitope as an Immediate Early Epitope Based on Transcription from an Upstream Gene
por: Fink, Annette, et al.
Publicado: (2014)

Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation
por: Gezinir, Emin, et al.
Publicado: (2020)

Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice
por: Thomas, Simone, et al.
Publicado: (2015)

Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation
por: Holtappels, Rafaela, et al.
Publicado: (2020)

Positive Role of the MHC Class-I Antigen Presentation Regulator m04/gp34 of Murine Cytomegalovirus in Antiviral Protection by CD8 T Cells
por: Becker, Sara, et al.
Publicado: (2020)

Strongyloides stercoralis Hyperinfection and Concomitant Cytomegalovirus Gastroenteritis in an Immunocompromised Host
por: Crowe, Brooks R., et al.
Publicado: (2019)

Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease
por: Reddehase, Matthias J.
Publicado: (2019)

Cytomegalovirus Esophagitis in an Immunocompromised Patient
por: Ali, Adya A, et al.
Publicado: (2023)

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells
por: Reuter, Sebastian, et al.
Publicado: (2019)

Mast Cells Expedite Control of Pulmonary Murine Cytomegalovirus Infection by Enhancing the Recruitment of Protective CD8 T Cells to the Lungs
por: Ebert, Stefan, et al.
Publicado: (2014)

Mutual Interference between Cytomegalovirus and Reconstitution of Protective Immunity after Hematopoietic Cell Transplantation
por: Reddehase, Matthias J.
Publicado: (2016)

Cytomegalovirus infection of the thyroid in immunocompromised adults.
por: Frank, T. S., et al.
Publicado: (1987)

Cytomegalovirus Cutaneous Infection in an Immunocompromised Patient
por: Fasanya, Adebayo A, et al.
Publicado: (2016)

Testing for Cytomegalovirus Among Individuals Who Were Immunocompromised, 2018-2022
por: Jain, Purva, et al.
Publicado: (2023)

Overlapping Infection by Strongyloides spp. and Cytomegalovirus in the Immunocompromised Host: A Comprehensive Review of the Literature
por: Lupia, Tommaso, et al.
Publicado: (2023)

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription
por: Chan, Baca, et al.
Publicado: (2017)

Cytomegalovirus immune evasion sets the functional avidity threshold for protection by CD8 T cells
por: Hamdan, Sara, et al.
Publicado: (2022)

Cytomegalovirus Misleads Its Host by Priming of CD8 T Cells Specific for an Epitope Not Presented in Infected Tissues
por: Holtappels, Rafaela, et al.
Publicado: (2004)

891. Cytomegalovirus Testing Rates Among Immunocompromised Adults, Adolescents, And Children In The United States
por: Jain, Purva, et al.
Publicado: (2023)

Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host
Publicado: (1988)

Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases
por: Ravikumar, Sharada, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_s6bbijan6u03m4dl2brt42kk64