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Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles

Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients’ signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusivel...

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Detalles Bibliográficos
Autores principales: Taguchi, Y-h., Wang, Hsiuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315543/
https://www.ncbi.nlm.nih.gov/pubmed/30563060
http://dx.doi.org/10.3390/cells7120245
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author Taguchi, Y-h.
Wang, Hsiuying
author_facet Taguchi, Y-h.
Wang, Hsiuying
author_sort Taguchi, Y-h.
collection PubMed
description Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients’ signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In this study, we explore both microRNA and gene biomarkers for PD. Microarray gene expression profiles for PD patients and healthy control are analyzed using a principal component analysis (PCA)-based unsupervised feature extraction (FE). 244 genes are selected to be potential gene biomarkers for PD. In addition, we implement these genes into Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and find that the 15 microRNAs (miRNAs), hsa-miR-92a-3p, 16-5p, 615-3p, 877-3p, 100-5p, 320a, 877-5p, 23a-3p, 484, 23b-3p, 15a-5p, 324-3p, 19b-3p, 7b-5p and 505-3p, significantly target these 244 genes. These miRNAs are shown to be significantly related to PD. This reveals that both selected genes and miRNAs are potential biomarkers for PD.
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spelling pubmed-63155432019-01-09 Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles Taguchi, Y-h. Wang, Hsiuying Cells Article Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients’ signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In this study, we explore both microRNA and gene biomarkers for PD. Microarray gene expression profiles for PD patients and healthy control are analyzed using a principal component analysis (PCA)-based unsupervised feature extraction (FE). 244 genes are selected to be potential gene biomarkers for PD. In addition, we implement these genes into Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and find that the 15 microRNAs (miRNAs), hsa-miR-92a-3p, 16-5p, 615-3p, 877-3p, 100-5p, 320a, 877-5p, 23a-3p, 484, 23b-3p, 15a-5p, 324-3p, 19b-3p, 7b-5p and 505-3p, significantly target these 244 genes. These miRNAs are shown to be significantly related to PD. This reveals that both selected genes and miRNAs are potential biomarkers for PD. MDPI 2018-12-05 /pmc/articles/PMC6315543/ /pubmed/30563060 http://dx.doi.org/10.3390/cells7120245 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Taguchi, Y-h.
Wang, Hsiuying
Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles
title Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles
title_full Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles
title_fullStr Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles
title_full_unstemmed Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles
title_short Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles
title_sort exploring microrna biomarkers for parkinson’s disease from mrna expression profiles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315543/
https://www.ncbi.nlm.nih.gov/pubmed/30563060
http://dx.doi.org/10.3390/cells7120245
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