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Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity

Background: Adenoid cystic carcinoma (ACC) are more common in the minor salivary glands (MiSGs) than the major salivary glands, and are characterized by slow tumor progression and frequently local recurrence. The main treatment option is surgery followed by combined radiotherapy. Methods: A retrospe...

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Autores principales: Lang, Kristin, Baur, Melissa, Akbaba, Sati, Held, Thomas, Kargus, Steffen, Bougatf, Nina, Bernhardt, Denise, Freier, Kolja, Plinkert, Peter K., Rieken, Stefan, Debus, Jürgen, Adeberg, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315550/
https://www.ncbi.nlm.nih.gov/pubmed/30518108
http://dx.doi.org/10.3390/cancers10120488
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author Lang, Kristin
Baur, Melissa
Akbaba, Sati
Held, Thomas
Kargus, Steffen
Bougatf, Nina
Bernhardt, Denise
Freier, Kolja
Plinkert, Peter K.
Rieken, Stefan
Debus, Jürgen
Adeberg, Sebastian
author_facet Lang, Kristin
Baur, Melissa
Akbaba, Sati
Held, Thomas
Kargus, Steffen
Bougatf, Nina
Bernhardt, Denise
Freier, Kolja
Plinkert, Peter K.
Rieken, Stefan
Debus, Jürgen
Adeberg, Sebastian
author_sort Lang, Kristin
collection PubMed
description Background: Adenoid cystic carcinoma (ACC) are more common in the minor salivary glands (MiSGs) than the major salivary glands, and are characterized by slow tumor progression and frequently local recurrence. The main treatment option is surgery followed by combined radiotherapy. Methods: A retrospective analysis contained 67 patients with ACC of MiSGs in the oral cavity who underwent surgery followed by radiotherapy. The median cumulative IMRT dose was 50 Gy followed by 24 Gy for carbon ion (C12) boost. Median follow-up was 40 months. Results: Median 5-years overall survival (OS), progression-free survival (PFS) and local disease-free survival (LDFS) rates were 85.5%, 57.4% and 74.9%. Median time until progression was detected was 32 months (range: 2–205 months). Early grade ≥3 mucositis, dermatitis, and dysphagia were detected in 52.2%, 7.5% and 11.9% respectively. Besides common toxicities, two patients (3.0%) developed grade 3 toxicities with osteoradionecrosis of the jaw after 18 and 66 months. Higher-grade late toxicity (CTCAE grade 4) was not detected. No treatment-related death was detected. Conclusions: Our results demonstrate that postoperative combined radiotherapy with IMRT plus C12 boost seems to be a feasible and effective treatment method in ACC of MiSGs in the oral cavity, with good control and survival rates and adequate toxicity.
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spelling pubmed-63155502019-01-09 Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity Lang, Kristin Baur, Melissa Akbaba, Sati Held, Thomas Kargus, Steffen Bougatf, Nina Bernhardt, Denise Freier, Kolja Plinkert, Peter K. Rieken, Stefan Debus, Jürgen Adeberg, Sebastian Cancers (Basel) Article Background: Adenoid cystic carcinoma (ACC) are more common in the minor salivary glands (MiSGs) than the major salivary glands, and are characterized by slow tumor progression and frequently local recurrence. The main treatment option is surgery followed by combined radiotherapy. Methods: A retrospective analysis contained 67 patients with ACC of MiSGs in the oral cavity who underwent surgery followed by radiotherapy. The median cumulative IMRT dose was 50 Gy followed by 24 Gy for carbon ion (C12) boost. Median follow-up was 40 months. Results: Median 5-years overall survival (OS), progression-free survival (PFS) and local disease-free survival (LDFS) rates were 85.5%, 57.4% and 74.9%. Median time until progression was detected was 32 months (range: 2–205 months). Early grade ≥3 mucositis, dermatitis, and dysphagia were detected in 52.2%, 7.5% and 11.9% respectively. Besides common toxicities, two patients (3.0%) developed grade 3 toxicities with osteoradionecrosis of the jaw after 18 and 66 months. Higher-grade late toxicity (CTCAE grade 4) was not detected. No treatment-related death was detected. Conclusions: Our results demonstrate that postoperative combined radiotherapy with IMRT plus C12 boost seems to be a feasible and effective treatment method in ACC of MiSGs in the oral cavity, with good control and survival rates and adequate toxicity. MDPI 2018-12-04 /pmc/articles/PMC6315550/ /pubmed/30518108 http://dx.doi.org/10.3390/cancers10120488 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lang, Kristin
Baur, Melissa
Akbaba, Sati
Held, Thomas
Kargus, Steffen
Bougatf, Nina
Bernhardt, Denise
Freier, Kolja
Plinkert, Peter K.
Rieken, Stefan
Debus, Jürgen
Adeberg, Sebastian
Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity
title Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity
title_full Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity
title_fullStr Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity
title_full_unstemmed Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity
title_short Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity
title_sort intensity modulated radiotherapy (imrt) + carbon ion boost for adenoid cystic carcinoma of the minor salivary glands in the oral cavity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315550/
https://www.ncbi.nlm.nih.gov/pubmed/30518108
http://dx.doi.org/10.3390/cancers10120488
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