Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor

Recently, the muscle-type nicotinic acetylcholine receptors (nAChRs) have been pursued as a potential target of several diseases, including myogenic disorders, muscle dystrophies and myasthenia gravis, etc. α-conotoxin GI isolated from Conus geographus selectively and potently inhibited the muscle-t...

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Detalles Bibliográficos
Autores principales: Ning, Jiong, Li, Rui, Ren, Jie, Zhangsun, Dongting, Zhu, Xiaopeng, Wu, Yong, Luo, Sulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315591/
https://www.ncbi.nlm.nih.gov/pubmed/30551685
http://dx.doi.org/10.3390/md16120507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315591/
https://www.ncbi.nlm.nih.gov/pubmed/30551685
http://dx.doi.org/10.3390/md16120507

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