Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis

Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid arthritis, and gout. This review summarizes the relevant data supporting a role for various TRP channels in arthritis pain an...

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Detalles Bibliográficos
Autores principales: Galindo, Tabitha, Reyna, Jose, Weyer, Andy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315622/
https://www.ncbi.nlm.nih.gov/pubmed/30326593
http://dx.doi.org/10.3390/ph11040105
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author Galindo, Tabitha
Reyna, Jose
Weyer, Andy
author_facet Galindo, Tabitha
Reyna, Jose
Weyer, Andy
author_sort Galindo, Tabitha
collection PubMed
description Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid arthritis, and gout. This review summarizes the relevant data supporting a role for various TRP channels in arthritis pain and pathogenesis, as well as the current state of pharmacological efforts to ameliorate arthritis symptoms in patient populations.
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spelling pubmed-63156222019-01-11 Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis Galindo, Tabitha Reyna, Jose Weyer, Andy Pharmaceuticals (Basel) Review Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid arthritis, and gout. This review summarizes the relevant data supporting a role for various TRP channels in arthritis pain and pathogenesis, as well as the current state of pharmacological efforts to ameliorate arthritis symptoms in patient populations. MDPI 2018-10-15 /pmc/articles/PMC6315622/ /pubmed/30326593 http://dx.doi.org/10.3390/ph11040105 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Galindo, Tabitha
Reyna, Jose
Weyer, Andy
Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis
title Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis
title_full Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis
title_fullStr Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis
title_full_unstemmed Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis
title_short Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis
title_sort evidence for transient receptor potential (trp) channel contribution to arthritis pain and pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315622/
https://www.ncbi.nlm.nih.gov/pubmed/30326593
http://dx.doi.org/10.3390/ph11040105
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