Loss of Myeloid-Specific TGF-β Signaling Decreases CTHRC1 to Downregulate bFGF and the Development of H1993-Induced Osteolytic Bone Lesions

The role of myeloid cell-specific TGF-β signaling in non-small-cell lung cancer (NSCLC)-induced osteolytic bone lesion development is unknown. We used a genetically engineered mouse model, Tgfbr2(LysMCre) knockout (KO), which has a loss of TGF-β signaling specifically in myeloid lineage cells, and w...

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Detalles Bibliográficos
Autores principales: Ganguly, Sourik S., Daft, Paul G., Cao, Jingchen, Meng, Xiangqi, Zhong, Zhendong A., Vander Ark, Alexandra, Meadows, Austin, Madaj, Zach, Williams, Bart, Li, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315699/
https://www.ncbi.nlm.nih.gov/pubmed/30469488
http://dx.doi.org/10.3390/cancers10120463

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