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Human Monoclonal scFvs that Neutralize Fribrinogenolytic Activity of Kaouthiagin, a Zinc-Metalloproteinase in Cobra (Naja kaouthia) Venom

Snake venom-metalloproteinases (SVMPs) are the primary factors that disturb hemostasis and cause hemorrhage in the venomous snake bitten subjects. Kaouthiagin is a unique SVMP that binds and cleaves von Willebrand factor (vWF) at a specific peptide bond leading to inhibition of platelet aggregation,...

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Detalles Bibliográficos
Autores principales:	Khanongnoi, Jirawat, Phanthong, Siratcha, Reamtong, Onrapak, Tungtronchitr, Anchalee, Chaicumpa, Wanpen, Sookrung, Nitat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315812/ https://www.ncbi.nlm.nih.gov/pubmed/30513883 http://dx.doi.org/10.3390/toxins10120509

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