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Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets
Multiple viruses with zoonotic potential have been isolated from bats globally. Here we describe the isolation and characterization of a novel paramyxovirus, Alston virus (AlsPV), isolated from urine collected from an Australian pteropid bat colony in Alstonville, New South Wales. Characterization o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315912/ https://www.ncbi.nlm.nih.gov/pubmed/30487438 http://dx.doi.org/10.3390/v10120675 |
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author | Johnson, Rebecca I. Tachedjian, Mary Rowe, Brenton Clayton, Bronwyn A. Layton, Rachel Bergfeld, Jemma Wang, Lin-Fa Marsh, Glenn A. |
author_facet | Johnson, Rebecca I. Tachedjian, Mary Rowe, Brenton Clayton, Bronwyn A. Layton, Rachel Bergfeld, Jemma Wang, Lin-Fa Marsh, Glenn A. |
author_sort | Johnson, Rebecca I. |
collection | PubMed |
description | Multiple viruses with zoonotic potential have been isolated from bats globally. Here we describe the isolation and characterization of a novel paramyxovirus, Alston virus (AlsPV), isolated from urine collected from an Australian pteropid bat colony in Alstonville, New South Wales. Characterization of AlsPV by whole-genome sequencing and analyzing antigenic relatedness revealed it is a rubulavirus that is closely related to parainfluenza virus 5 (PIV5). Intranasal exposure of mice to AlsPV resulted in no clinical signs of disease, although viral RNA was detected in the olfactory bulbs of two mice at 21 days post exposure. Oronasal challenge of ferrets resulted in subclinical upper respiratory tract infection, viral shedding in respiratory secretions, and detection of viral antigen in the olfactory bulb of the brain. These results imply that AlsPV may be similar to PIV5 in its ability to infect multiple mammalian host species. This isolation of a novel paramyxovirus with the potential to transmit from bats to other mammalian species reinforces the importance of continued surveillance of bats as a source of emerging viruses. |
format | Online Article Text |
id | pubmed-6315912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63159122019-01-10 Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets Johnson, Rebecca I. Tachedjian, Mary Rowe, Brenton Clayton, Bronwyn A. Layton, Rachel Bergfeld, Jemma Wang, Lin-Fa Marsh, Glenn A. Viruses Article Multiple viruses with zoonotic potential have been isolated from bats globally. Here we describe the isolation and characterization of a novel paramyxovirus, Alston virus (AlsPV), isolated from urine collected from an Australian pteropid bat colony in Alstonville, New South Wales. Characterization of AlsPV by whole-genome sequencing and analyzing antigenic relatedness revealed it is a rubulavirus that is closely related to parainfluenza virus 5 (PIV5). Intranasal exposure of mice to AlsPV resulted in no clinical signs of disease, although viral RNA was detected in the olfactory bulbs of two mice at 21 days post exposure. Oronasal challenge of ferrets resulted in subclinical upper respiratory tract infection, viral shedding in respiratory secretions, and detection of viral antigen in the olfactory bulb of the brain. These results imply that AlsPV may be similar to PIV5 in its ability to infect multiple mammalian host species. This isolation of a novel paramyxovirus with the potential to transmit from bats to other mammalian species reinforces the importance of continued surveillance of bats as a source of emerging viruses. MDPI 2018-11-28 /pmc/articles/PMC6315912/ /pubmed/30487438 http://dx.doi.org/10.3390/v10120675 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Johnson, Rebecca I. Tachedjian, Mary Rowe, Brenton Clayton, Bronwyn A. Layton, Rachel Bergfeld, Jemma Wang, Lin-Fa Marsh, Glenn A. Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets |
title | Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets |
title_full | Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets |
title_fullStr | Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets |
title_full_unstemmed | Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets |
title_short | Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets |
title_sort | alston virus, a novel paramyxovirus isolated from bats causes upper respiratory tract infection in experimentally challenged ferrets |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315912/ https://www.ncbi.nlm.nih.gov/pubmed/30487438 http://dx.doi.org/10.3390/v10120675 |
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