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Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PU...

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Detalles Bibliográficos
Autores principales: Sánchez-Villegas, Almudena, Álvarez-Pérez, Jacqueline, Toledo, Estefanía, Salas-Salvadó, Jordi, Ortega-Azorín, Carolina, Zomeño, Maria Dolores, Vioque, Jesús, Martínez, Jose Alfredo, Romaguera, Dora, Pérez-López, Jessica, López-Miranda, José, Estruch, Ramón, Bueno-Cavanillas, Aurora, Arós, Fernando, Tur, Josep A., Tinahones, Francisco J., Lecea, Oscar, Martín, Vicente, Ortega-Calvo, M., Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Delgado-Rodríguez, Miguel, Matía, Pilar, Corella, Dolores, Díaz-López, Andrés, Babio, Nancy, Muñoz, Miguel Ángel, Fitó, Montserrat, García de la Hera, Manoli, Abete, Itziar, García-Rios, Antonio, Ros, Emilio, Ruíz-Canela, Miguel, Martínez-González, Miguel Ángel, Izquierdo, Marisol, Serra-Majem, Lluis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315981/
https://www.ncbi.nlm.nih.gov/pubmed/30567286
http://dx.doi.org/10.3390/nu10122000
Descripción
Sumario:Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63–0.94), 0.71 (0.58–0.87), and 0.78 (0.64–0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5–1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.