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Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset

Background: Few studies have reported the epidemiology and clinical outcome of venous thromboembolism (VTE) in Asian patients with pancreatic cancer. This study investigated the incidence, risk factors, and clinical outcome of VTE in patients with pancreatic cancer following palliative chemotherapy....

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Autores principales: Chen, Jen-Shi, Hung, Chia-Yen, Chang, Hung, Liu, Chien-Ting, Chen, Yen-Yang, Lu, Chang-Hsien, Chang, Pei-Hung, Hung, Yu-Shin, Chou, Wen-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315992/
https://www.ncbi.nlm.nih.gov/pubmed/30544670
http://dx.doi.org/10.3390/cancers10120501
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author Chen, Jen-Shi
Hung, Chia-Yen
Chang, Hung
Liu, Chien-Ting
Chen, Yen-Yang
Lu, Chang-Hsien
Chang, Pei-Hung
Hung, Yu-Shin
Chou, Wen-Chi
author_facet Chen, Jen-Shi
Hung, Chia-Yen
Chang, Hung
Liu, Chien-Ting
Chen, Yen-Yang
Lu, Chang-Hsien
Chang, Pei-Hung
Hung, Yu-Shin
Chou, Wen-Chi
author_sort Chen, Jen-Shi
collection PubMed
description Background: Few studies have reported the epidemiology and clinical outcome of venous thromboembolism (VTE) in Asian patients with pancreatic cancer. This study investigated the incidence, risk factors, and clinical outcome of VTE in patients with pancreatic cancer following palliative chemotherapy. Methods: The medical records of 838 patients with newly diagnosed locally advanced or metastatic pancreatic cancer who underwent palliative chemotherapy between 2010 and 2016 at four institutes in Taiwan were retrospectively reviewed. The clinical characteristics of all patients were analyzed to identify independent predictors of VTE and their effects on survival outcome. Results: During the median follow-up period of 7.7 months (range, 0.6–55.6), VTE occurred in 67 (8.0%) of the 838 patients. Leukocyte count > 11,000/μL and presence of liver metastases were the independent predictors of VTE. Patients with VTE did not show significantly poorer survival outcomes than those without VTE. However, early-onset VTE that occurred within 1.5 months after chemotherapy initiation was an independent negative prognosticator for overall survival. Conclusion: VTE incidence was found to be lower in Asian patients with pancreatic cancer than in their Western counterparts. Early-onset VTE, but not late-onset VTE, is a negative prognosticator for survival outcomes.
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spelling pubmed-63159922019-01-09 Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset Chen, Jen-Shi Hung, Chia-Yen Chang, Hung Liu, Chien-Ting Chen, Yen-Yang Lu, Chang-Hsien Chang, Pei-Hung Hung, Yu-Shin Chou, Wen-Chi Cancers (Basel) Article Background: Few studies have reported the epidemiology and clinical outcome of venous thromboembolism (VTE) in Asian patients with pancreatic cancer. This study investigated the incidence, risk factors, and clinical outcome of VTE in patients with pancreatic cancer following palliative chemotherapy. Methods: The medical records of 838 patients with newly diagnosed locally advanced or metastatic pancreatic cancer who underwent palliative chemotherapy between 2010 and 2016 at four institutes in Taiwan were retrospectively reviewed. The clinical characteristics of all patients were analyzed to identify independent predictors of VTE and their effects on survival outcome. Results: During the median follow-up period of 7.7 months (range, 0.6–55.6), VTE occurred in 67 (8.0%) of the 838 patients. Leukocyte count > 11,000/μL and presence of liver metastases were the independent predictors of VTE. Patients with VTE did not show significantly poorer survival outcomes than those without VTE. However, early-onset VTE that occurred within 1.5 months after chemotherapy initiation was an independent negative prognosticator for overall survival. Conclusion: VTE incidence was found to be lower in Asian patients with pancreatic cancer than in their Western counterparts. Early-onset VTE, but not late-onset VTE, is a negative prognosticator for survival outcomes. MDPI 2018-12-10 /pmc/articles/PMC6315992/ /pubmed/30544670 http://dx.doi.org/10.3390/cancers10120501 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Jen-Shi
Hung, Chia-Yen
Chang, Hung
Liu, Chien-Ting
Chen, Yen-Yang
Lu, Chang-Hsien
Chang, Pei-Hung
Hung, Yu-Shin
Chou, Wen-Chi
Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset
title Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset
title_full Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset
title_fullStr Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset
title_full_unstemmed Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset
title_short Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset
title_sort venous thromboembolism in asian patients with pancreatic cancer following palliative chemotherapy: low incidence but a negative prognosticator for those with early onset
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315992/
https://www.ncbi.nlm.nih.gov/pubmed/30544670
http://dx.doi.org/10.3390/cancers10120501
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