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Impaired Glucose Tolerance in Adults with Duchenne and Becker Muscular Dystrophy

The aim of this study was to determine the response to an oral glucose tolerance test (OGTT) in adult males with Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD), and to investigate whether body composition contributes to any variance in the glucose response. Twenty-eight adult...

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Autores principales: Bostock, Emma L., Edwards, Bryn T., Jacques, Matthew F., Pogson, Jake T.S., Reeves, Neil D., Onambele-Pearson, Gladys L., Morse, Christopher I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316013/
https://www.ncbi.nlm.nih.gov/pubmed/30544630
http://dx.doi.org/10.3390/nu10121947
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author Bostock, Emma L.
Edwards, Bryn T.
Jacques, Matthew F.
Pogson, Jake T.S.
Reeves, Neil D.
Onambele-Pearson, Gladys L.
Morse, Christopher I.
author_facet Bostock, Emma L.
Edwards, Bryn T.
Jacques, Matthew F.
Pogson, Jake T.S.
Reeves, Neil D.
Onambele-Pearson, Gladys L.
Morse, Christopher I.
author_sort Bostock, Emma L.
collection PubMed
description The aim of this study was to determine the response to an oral glucose tolerance test (OGTT) in adult males with Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD), and to investigate whether body composition contributes to any variance in the glucose response. Twenty-eight adult males with dystrophinopathy (BMD, n = 13; DMD, n = 15) and 12 non-dystrophic controls, ingested 75 g oral anhydrous glucose solution. Fingertip capillary samples were assessed for glucose at 30-min intervals over 2-h post glucose ingestion. Fat free mass relative to body mass (FFM/BM) and body fat (BF%) was assessed using bioelectrical impedance. Vastus lateralis muscle anatomical cross sectional area (VL ACSA) was measured using B-mode ultrasonography. Blood glucose was higher in MD groups than control at 60, 90 and 120 min post ingestion of glucose. Compared to controls, FFM/BM and VL ACSA were lower in MD groups compared to controls (p < 0.001). Glucose tolerance values at 120 min were correlated with FFM/BM and BF% in the BMD group only. Our results suggest that glucose tolerance is impaired following OGTT in adult males with BMD and DMD. It is recommended that adults with BMD and DMD undertake routine glucose tolerance assessments to allow early detection of impaired glucose tolerance.
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spelling pubmed-63160132019-01-08 Impaired Glucose Tolerance in Adults with Duchenne and Becker Muscular Dystrophy Bostock, Emma L. Edwards, Bryn T. Jacques, Matthew F. Pogson, Jake T.S. Reeves, Neil D. Onambele-Pearson, Gladys L. Morse, Christopher I. Nutrients Article The aim of this study was to determine the response to an oral glucose tolerance test (OGTT) in adult males with Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD), and to investigate whether body composition contributes to any variance in the glucose response. Twenty-eight adult males with dystrophinopathy (BMD, n = 13; DMD, n = 15) and 12 non-dystrophic controls, ingested 75 g oral anhydrous glucose solution. Fingertip capillary samples were assessed for glucose at 30-min intervals over 2-h post glucose ingestion. Fat free mass relative to body mass (FFM/BM) and body fat (BF%) was assessed using bioelectrical impedance. Vastus lateralis muscle anatomical cross sectional area (VL ACSA) was measured using B-mode ultrasonography. Blood glucose was higher in MD groups than control at 60, 90 and 120 min post ingestion of glucose. Compared to controls, FFM/BM and VL ACSA were lower in MD groups compared to controls (p < 0.001). Glucose tolerance values at 120 min were correlated with FFM/BM and BF% in the BMD group only. Our results suggest that glucose tolerance is impaired following OGTT in adult males with BMD and DMD. It is recommended that adults with BMD and DMD undertake routine glucose tolerance assessments to allow early detection of impaired glucose tolerance. MDPI 2018-12-07 /pmc/articles/PMC6316013/ /pubmed/30544630 http://dx.doi.org/10.3390/nu10121947 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bostock, Emma L.
Edwards, Bryn T.
Jacques, Matthew F.
Pogson, Jake T.S.
Reeves, Neil D.
Onambele-Pearson, Gladys L.
Morse, Christopher I.
Impaired Glucose Tolerance in Adults with Duchenne and Becker Muscular Dystrophy
title Impaired Glucose Tolerance in Adults with Duchenne and Becker Muscular Dystrophy
title_full Impaired Glucose Tolerance in Adults with Duchenne and Becker Muscular Dystrophy
title_fullStr Impaired Glucose Tolerance in Adults with Duchenne and Becker Muscular Dystrophy
title_full_unstemmed Impaired Glucose Tolerance in Adults with Duchenne and Becker Muscular Dystrophy
title_short Impaired Glucose Tolerance in Adults with Duchenne and Becker Muscular Dystrophy
title_sort impaired glucose tolerance in adults with duchenne and becker muscular dystrophy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316013/
https://www.ncbi.nlm.nih.gov/pubmed/30544630
http://dx.doi.org/10.3390/nu10121947
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