Cargando…
Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release
The aim of the present study was the development of a “smart bandage” for the topical administration of diclofenac, in the treatment of localized painful and inflammatory conditions, incorporating Molecularly Imprinted Polymers (MIPs) for the controlled release of this anti-inflammatory drug. For th...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316117/ https://www.ncbi.nlm.nih.gov/pubmed/30248997 http://dx.doi.org/10.3390/ph11040092 |
_version_ | 1783384453764087808 |
---|---|
author | Parisi, Ortensia Ilaria Ruffo, Mariarosa Scrivano, Luca Malivindi, Rocco Vassallo, Antonio Puoci, Francesco |
author_facet | Parisi, Ortensia Ilaria Ruffo, Mariarosa Scrivano, Luca Malivindi, Rocco Vassallo, Antonio Puoci, Francesco |
author_sort | Parisi, Ortensia Ilaria |
collection | PubMed |
description | The aim of the present study was the development of a “smart bandage” for the topical administration of diclofenac, in the treatment of localized painful and inflammatory conditions, incorporating Molecularly Imprinted Polymers (MIPs) for the controlled release of this anti-inflammatory drug. For this purpose, MIP spherical particles were synthesized by precipitation polymerization, loaded with the therapeutic agent and incorporated into the bandage surface. Batch adsorption binding studies were performed to investigate the adsorption isotherms and kinetics and the selective recognition abilities of the synthesized MIP. In vitro diffusion studies were also carried out using Franz cells and the obtained results were reported as percentage of the diffused dose, cumulative amount of diffused drug, steady-state drug flux and permeability coefficient. Moreover, the biocompatibility of the developed device was evaluated using the EPISKIN™ model. The Scatchard analysis indicated that the prepared MIP is characterized by the presence of specific binding sites for diclofenac, which are not present in the corresponding non-imprinted polymer, and the obtained results confirmed both the ability of the prepared bandage to prolong the drug release and the absence of skin irritation reactions. Therefore, these results support the potential application of the developed “smart bandage” as topical device for diclofenac sustained release. |
format | Online Article Text |
id | pubmed-6316117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63161172019-01-11 Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release Parisi, Ortensia Ilaria Ruffo, Mariarosa Scrivano, Luca Malivindi, Rocco Vassallo, Antonio Puoci, Francesco Pharmaceuticals (Basel) Article The aim of the present study was the development of a “smart bandage” for the topical administration of diclofenac, in the treatment of localized painful and inflammatory conditions, incorporating Molecularly Imprinted Polymers (MIPs) for the controlled release of this anti-inflammatory drug. For this purpose, MIP spherical particles were synthesized by precipitation polymerization, loaded with the therapeutic agent and incorporated into the bandage surface. Batch adsorption binding studies were performed to investigate the adsorption isotherms and kinetics and the selective recognition abilities of the synthesized MIP. In vitro diffusion studies were also carried out using Franz cells and the obtained results were reported as percentage of the diffused dose, cumulative amount of diffused drug, steady-state drug flux and permeability coefficient. Moreover, the biocompatibility of the developed device was evaluated using the EPISKIN™ model. The Scatchard analysis indicated that the prepared MIP is characterized by the presence of specific binding sites for diclofenac, which are not present in the corresponding non-imprinted polymer, and the obtained results confirmed both the ability of the prepared bandage to prolong the drug release and the absence of skin irritation reactions. Therefore, these results support the potential application of the developed “smart bandage” as topical device for diclofenac sustained release. MDPI 2018-09-22 /pmc/articles/PMC6316117/ /pubmed/30248997 http://dx.doi.org/10.3390/ph11040092 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Parisi, Ortensia Ilaria Ruffo, Mariarosa Scrivano, Luca Malivindi, Rocco Vassallo, Antonio Puoci, Francesco Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release |
title | Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release |
title_full | Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release |
title_fullStr | Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release |
title_full_unstemmed | Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release |
title_short | Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release |
title_sort | smart bandage based on molecularly imprinted polymers (mips) for diclofenac controlled release |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316117/ https://www.ncbi.nlm.nih.gov/pubmed/30248997 http://dx.doi.org/10.3390/ph11040092 |
work_keys_str_mv | AT parisiortensiailaria smartbandagebasedonmolecularlyimprintedpolymersmipsfordiclofenaccontrolledrelease AT ruffomariarosa smartbandagebasedonmolecularlyimprintedpolymersmipsfordiclofenaccontrolledrelease AT scrivanoluca smartbandagebasedonmolecularlyimprintedpolymersmipsfordiclofenaccontrolledrelease AT malivindirocco smartbandagebasedonmolecularlyimprintedpolymersmipsfordiclofenaccontrolledrelease AT vassalloantonio smartbandagebasedonmolecularlyimprintedpolymersmipsfordiclofenaccontrolledrelease AT puocifrancesco smartbandagebasedonmolecularlyimprintedpolymersmipsfordiclofenaccontrolledrelease |