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Monitoring Thermal Ablation via Microwave Tomography: An Ex Vivo Experimental Assessment

Thermal ablation treatments are gaining a lot of attention in the clinics thanks to their reduced invasiveness and their capability of treating non-surgical patients. The effectiveness of these treatments and their impact in the hospital’s routine would significantly increase if paired with a monito...

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Autores principales: Scapaticci, Rosa, Lopresto, Vanni, Pinto, Rosanna, Cavagnaro, Marta, Crocco, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316129/
https://www.ncbi.nlm.nih.gov/pubmed/30563280
http://dx.doi.org/10.3390/diagnostics8040081
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author Scapaticci, Rosa
Lopresto, Vanni
Pinto, Rosanna
Cavagnaro, Marta
Crocco, Lorenzo
author_facet Scapaticci, Rosa
Lopresto, Vanni
Pinto, Rosanna
Cavagnaro, Marta
Crocco, Lorenzo
author_sort Scapaticci, Rosa
collection PubMed
description Thermal ablation treatments are gaining a lot of attention in the clinics thanks to their reduced invasiveness and their capability of treating non-surgical patients. The effectiveness of these treatments and their impact in the hospital’s routine would significantly increase if paired with a monitoring technique able to control the evolution of the treated area in real-time. This is particularly relevant in microwave thermal ablation, wherein the capability of treating larger tumors in a shorter time needs proper monitoring. Current diagnostic imaging techniques do not provide effective solutions to this issue for a number of reasons, including economical sustainability and safety. Hence, the development of alternative modalities is of interest. Microwave tomography, which aims at imaging the electromagnetic properties of a target under test, has been recently proposed for this scope, given the significant temperature-dependent changes of the dielectric properties of human tissues induced by thermal ablation. In this paper, the outcomes of the first ex vivo experimental study, performed to assess the expected potentialities of microwave tomography, are presented. The paper describes the validation study dealing with the imaging of the changes occurring in thermal ablation treatments. The experimental test was carried out on two ex vivo bovine liver samples and the reported results show the capability of microwave tomography of imaging the transition between ablated and untreated tissue. Moreover, the discussion section provides some guidelines to follow in order to improve the achievable performances.
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spelling pubmed-63161292019-01-11 Monitoring Thermal Ablation via Microwave Tomography: An Ex Vivo Experimental Assessment Scapaticci, Rosa Lopresto, Vanni Pinto, Rosanna Cavagnaro, Marta Crocco, Lorenzo Diagnostics (Basel) Article Thermal ablation treatments are gaining a lot of attention in the clinics thanks to their reduced invasiveness and their capability of treating non-surgical patients. The effectiveness of these treatments and their impact in the hospital’s routine would significantly increase if paired with a monitoring technique able to control the evolution of the treated area in real-time. This is particularly relevant in microwave thermal ablation, wherein the capability of treating larger tumors in a shorter time needs proper monitoring. Current diagnostic imaging techniques do not provide effective solutions to this issue for a number of reasons, including economical sustainability and safety. Hence, the development of alternative modalities is of interest. Microwave tomography, which aims at imaging the electromagnetic properties of a target under test, has been recently proposed for this scope, given the significant temperature-dependent changes of the dielectric properties of human tissues induced by thermal ablation. In this paper, the outcomes of the first ex vivo experimental study, performed to assess the expected potentialities of microwave tomography, are presented. The paper describes the validation study dealing with the imaging of the changes occurring in thermal ablation treatments. The experimental test was carried out on two ex vivo bovine liver samples and the reported results show the capability of microwave tomography of imaging the transition between ablated and untreated tissue. Moreover, the discussion section provides some guidelines to follow in order to improve the achievable performances. MDPI 2018-12-06 /pmc/articles/PMC6316129/ /pubmed/30563280 http://dx.doi.org/10.3390/diagnostics8040081 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scapaticci, Rosa
Lopresto, Vanni
Pinto, Rosanna
Cavagnaro, Marta
Crocco, Lorenzo
Monitoring Thermal Ablation via Microwave Tomography: An Ex Vivo Experimental Assessment
title Monitoring Thermal Ablation via Microwave Tomography: An Ex Vivo Experimental Assessment
title_full Monitoring Thermal Ablation via Microwave Tomography: An Ex Vivo Experimental Assessment
title_fullStr Monitoring Thermal Ablation via Microwave Tomography: An Ex Vivo Experimental Assessment
title_full_unstemmed Monitoring Thermal Ablation via Microwave Tomography: An Ex Vivo Experimental Assessment
title_short Monitoring Thermal Ablation via Microwave Tomography: An Ex Vivo Experimental Assessment
title_sort monitoring thermal ablation via microwave tomography: an ex vivo experimental assessment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316129/
https://www.ncbi.nlm.nih.gov/pubmed/30563280
http://dx.doi.org/10.3390/diagnostics8040081
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