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Liquid Biopsy in Gastrointestinal Cancers

Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal moni...

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Autores principales: Saini, Aman, Pershad, Yash, Albadawi, Hassan, Kuo, Malia, Alzubaidi, Sadeer, Naidu, Sailendra, Knuttinen, M-Grace, Oklu, Rahmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316210/
https://www.ncbi.nlm.nih.gov/pubmed/30380690
http://dx.doi.org/10.3390/diagnostics8040075
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author Saini, Aman
Pershad, Yash
Albadawi, Hassan
Kuo, Malia
Alzubaidi, Sadeer
Naidu, Sailendra
Knuttinen, M-Grace
Oklu, Rahmi
author_facet Saini, Aman
Pershad, Yash
Albadawi, Hassan
Kuo, Malia
Alzubaidi, Sadeer
Naidu, Sailendra
Knuttinen, M-Grace
Oklu, Rahmi
author_sort Saini, Aman
collection PubMed
description Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics.
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spelling pubmed-63162102019-01-11 Liquid Biopsy in Gastrointestinal Cancers Saini, Aman Pershad, Yash Albadawi, Hassan Kuo, Malia Alzubaidi, Sadeer Naidu, Sailendra Knuttinen, M-Grace Oklu, Rahmi Diagnostics (Basel) Review Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics. MDPI 2018-10-29 /pmc/articles/PMC6316210/ /pubmed/30380690 http://dx.doi.org/10.3390/diagnostics8040075 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saini, Aman
Pershad, Yash
Albadawi, Hassan
Kuo, Malia
Alzubaidi, Sadeer
Naidu, Sailendra
Knuttinen, M-Grace
Oklu, Rahmi
Liquid Biopsy in Gastrointestinal Cancers
title Liquid Biopsy in Gastrointestinal Cancers
title_full Liquid Biopsy in Gastrointestinal Cancers
title_fullStr Liquid Biopsy in Gastrointestinal Cancers
title_full_unstemmed Liquid Biopsy in Gastrointestinal Cancers
title_short Liquid Biopsy in Gastrointestinal Cancers
title_sort liquid biopsy in gastrointestinal cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316210/
https://www.ncbi.nlm.nih.gov/pubmed/30380690
http://dx.doi.org/10.3390/diagnostics8040075
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