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Liquid Biopsy in Gastrointestinal Cancers
Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal moni...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316210/ https://www.ncbi.nlm.nih.gov/pubmed/30380690 http://dx.doi.org/10.3390/diagnostics8040075 |
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author | Saini, Aman Pershad, Yash Albadawi, Hassan Kuo, Malia Alzubaidi, Sadeer Naidu, Sailendra Knuttinen, M-Grace Oklu, Rahmi |
author_facet | Saini, Aman Pershad, Yash Albadawi, Hassan Kuo, Malia Alzubaidi, Sadeer Naidu, Sailendra Knuttinen, M-Grace Oklu, Rahmi |
author_sort | Saini, Aman |
collection | PubMed |
description | Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics. |
format | Online Article Text |
id | pubmed-6316210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63162102019-01-11 Liquid Biopsy in Gastrointestinal Cancers Saini, Aman Pershad, Yash Albadawi, Hassan Kuo, Malia Alzubaidi, Sadeer Naidu, Sailendra Knuttinen, M-Grace Oklu, Rahmi Diagnostics (Basel) Review Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics. MDPI 2018-10-29 /pmc/articles/PMC6316210/ /pubmed/30380690 http://dx.doi.org/10.3390/diagnostics8040075 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Saini, Aman Pershad, Yash Albadawi, Hassan Kuo, Malia Alzubaidi, Sadeer Naidu, Sailendra Knuttinen, M-Grace Oklu, Rahmi Liquid Biopsy in Gastrointestinal Cancers |
title | Liquid Biopsy in Gastrointestinal Cancers |
title_full | Liquid Biopsy in Gastrointestinal Cancers |
title_fullStr | Liquid Biopsy in Gastrointestinal Cancers |
title_full_unstemmed | Liquid Biopsy in Gastrointestinal Cancers |
title_short | Liquid Biopsy in Gastrointestinal Cancers |
title_sort | liquid biopsy in gastrointestinal cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316210/ https://www.ncbi.nlm.nih.gov/pubmed/30380690 http://dx.doi.org/10.3390/diagnostics8040075 |
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