Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers

Pharmaceutical reactivation of lytic cycle of Epstein–Barr virus (EBV) represents a potential therapeutic strategy against EBV-associated epithelial malignancies, e.g., gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). A novel lytic-inducing compound, C7, which exhibits structural similarit...

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Detalles Bibliográficos
Autores principales: Yiu, Stephanie Pei Tung, Hui, Kwai Fung, Choi, Chung King, Kao, Richard Yi Tsun, Ma, Chi Wang, Yang, Dan, Chiang, Alan Kwok Shing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316324/
https://www.ncbi.nlm.nih.gov/pubmed/30544928
http://dx.doi.org/10.3390/cancers10120505

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