Cargando…

PCA-Based Multiple-Trait GWAS Analysis: A Powerful Model for Exploring Pleiotropy

SIMPLE SUMMARY: In biological processes, it is common that a single gene controls two or more traits, leading to a high genetically correlation between many traits in human beings and livestock. Genome-wide association study (GWAS) is a popular method for mapping causal genes or regions related to s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wengang, Gao, Xue, Shi, Xinping, Zhu, Bo, Wang, Zezhao, Gao, Huijiang, Xu, Lingyang, Zhang, Lupei, Li, Junya, Chen, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316348/ https://www.ncbi.nlm.nih.gov/pubmed/30562943 http://dx.doi.org/10.3390/ani8120239

Ejemplares similares

Genomic Prediction and Association Analysis with Models Including Dominance Effects for Important Traits in Chinese Simmental Beef Cattle
por: Liu, Ying, et al.
Publicado: (2019)

Genome-wide scan reveals genetic divergence and diverse adaptive selection in Chinese local cattle
por: Xu, Lingyang, et al.
Publicado: (2019)

Incorporating Genome Annotation Into Genomic Prediction for Carcass Traits in Chinese Simmental Beef Cattle
por: Xu, Ling, et al.
Publicado: (2020)

The eQTL colocalization and transcriptome-wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle
por: Cai, Wentao, et al.
Publicado: (2023)

Genome wide association study identifies SNPs associated with fatty acid composition in Chinese Wagyu cattle
por: Wang, Zezhao, et al.
Publicado: (2019)

Runs of homozygosity analysis reveals consensus homozygous regions affecting production traits in Chinese Simmental beef cattle
por: Zhao, Guoyao, et al.
Publicado: (2021)

Validation of the Prediction Accuracy for 13 Traits in Chinese Simmental Beef Cattle Using a Preselected Low-Density SNP Panel
por: Xu, Ling, et al.
Publicado: (2021)

Genomic prediction of carcass traits using different haplotype block partitioning methods in beef cattle
por: Li, Hongwei, et al.
Publicado: (2022)

Weighted Single-Step Genome-Wide Association Study for Growth Traits in Chinese Simmental Beef Cattle
por: Zhuang, Zhanwei, et al.
Publicado: (2020)

Searching for new loci and candidate genes for economically important traits through gene-based association analysis of Simmental cattle
por: Xia, Jiangwei, et al.
Publicado: (2017)

Genomic prediction with parallel computing for slaughter traits in Chinese Simmental beef cattle using high-density genotypes
por: Guo, Peng, et al.
Publicado: (2017)

Genome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP array
por: Zhu, Bo, et al.
Publicado: (2017)

Multi-strategy genome-wide association studies identify the DCAF16-NCAPG region as a susceptibility locus for average daily gain in cattle
por: Zhang, Wengang, et al.
Publicado: (2016)

Evaluation of Linkage Disequilibrium, Effective Population Size and Haplotype Block Structure in Chinese Cattle
por: Xu, Lei, et al.
Publicado: (2019)

Identification of Candidate Variants Associated With Bone Weight Using Whole Genome Sequence in Beef Cattle
por: Niu, Qunhao, et al.
Publicado: (2021)

Genome-Wide Assessment of Runs of Homozygosity in Chinese Wagyu Beef Cattle
por: Zhao, Guoyao, et al.
Publicado: (2020)

Genome-Wide Association Study Reveals the PLAG1 Gene for Knuckle, Biceps and Shank Weight in Simmental Beef Cattle
por: Song, Yuxin, et al.
Publicado: (2016)

Genome-Wide Scan Identifies Selection Signatures in Chinese Wagyu Cattle Using a High-Density SNP Array
por: Wang, Zezhao, et al.
Publicado: (2019)

Theoretical Evaluation of Multi-Breed Genomic Prediction in Chinese Indigenous Cattle
por: Xu, Lei, et al.
Publicado: (2019)

A Fast and Powerful Empirical Bayes Method for Genome-Wide Association Studies
por: Chang, Tianpeng, et al.
Publicado: (2019)

Genome-wide assessment of genetic diversity and population structure insights into admixture and introgression in Chinese indigenous cattle
por: Zhang, Wengang, et al.
Publicado: (2018)

Assessing the Genetic Background and Selection Signatures of Huaxi Cattle Using High-Density SNP Array
por: Ma, Jun, et al.
Publicado: (2021)

Constructing a comprehensive gene co-expression based interactome in Bos taurus
por: Chen, Yan, et al.
Publicado: (2017)

Identification of muscle-specific candidate genes in Simmental beef cattle using imputed next generation sequencing
por: Bordbar, Farhad, et al.
Publicado: (2019)

Genome-wide analysis reveals differential selection involved with copy number variation in diverse Chinese Cattle
por: Yang, Liu, et al.
Publicado: (2017)

Transcriptome Analysis of Bovine Rumen Tissue in Three Developmental Stages
por: Zhang, Yapeng, et al.
Publicado: (2022)

Transcriptional states and chromatin accessibility during bovine myoblasts proliferation and myogenic differentiation
por: Li, Qian, et al.
Publicado: (2022)

Genomic Prediction Using LD-Based Haplotypes Inferred From High-Density Chip and Imputed Sequence Variants in Chinese Simmental Beef Cattle
por: Li, Hongwei, et al.
Publicado: (2021)

Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits
por: Chun, Sung, et al.
Publicado: (2022)

Cis-eQTL Analysis and Functional Validation of Candidate Genes for Carcass Yield Traits in Beef Cattle
por: Wang, Tianzhen, et al.
Publicado: (2022)

Pathway-Based Genome-Wide Association Studies for Two Meat Production Traits in Simmental Cattle
por: Fan, Huizhong, et al.
Publicado: (2015)

Transcriptional atlas analysis from multiple tissues reveals the expression specificity patterns in beef cattle
por: Zhang, Tianliu, et al.
Publicado: (2022)

Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data
por: Xue, Haoran, et al.
Publicado: (2020)

Fast genomic prediction of breeding values using parallel Markov chain Monte Carlo with convergence diagnosis
por: Guo, Peng, et al.
Publicado: (2018)

Characterization of Chromatin Accessibility in Fetal Bovine Chondrocytes
por: Zhang, Qi, et al.
Publicado: (2023)

Probe-based association analysis identifies several deletions associated with average daily gain in beef cattle
por: Xu, Lingyang, et al.
Publicado: (2019)

Genomic Patterns of Homozygosity in Chinese Local Cattle
por: Xu, Lingyang, et al.
Publicado: (2019)

Comparative Transcriptome Analyses of Gayal (Bos frontalis), Yak (Bos grunniens), and Cattle (Bos taurus) Reveal the High-Altitude Adaptation
por: Ma, Jun, et al.
Publicado: (2022)

Evaluation of GBLUP, BayesB and elastic net for genomic prediction in Chinese Simmental beef cattle
por: Wang, Xiaoqiao, et al.
Publicado: (2019)

Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits
por: Gleason, Kevin J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ognfr1dd0rubeqc9bs6nhap7el