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Recombinant Viruses for Cancer Therapy

Recombinant viruses are novel therapeutic agents that can be utilized for treatment of various diseases, including cancers. Recombinant viruses can be engineered to express foreign transgenes and have a broad tropism allowing gene expression in a wide range of host cells. They can be selected or des...

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Autores principales: Chulpanova, Daria S., Solovyeva, Valeriya V., Kitaeva, Kristina V., Dunham, Stephen P., Khaiboullina, Svetlana F., Rizvanov, Albert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316473/
https://www.ncbi.nlm.nih.gov/pubmed/30257488
http://dx.doi.org/10.3390/biomedicines6040094
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author Chulpanova, Daria S.
Solovyeva, Valeriya V.
Kitaeva, Kristina V.
Dunham, Stephen P.
Khaiboullina, Svetlana F.
Rizvanov, Albert A.
author_facet Chulpanova, Daria S.
Solovyeva, Valeriya V.
Kitaeva, Kristina V.
Dunham, Stephen P.
Khaiboullina, Svetlana F.
Rizvanov, Albert A.
author_sort Chulpanova, Daria S.
collection PubMed
description Recombinant viruses are novel therapeutic agents that can be utilized for treatment of various diseases, including cancers. Recombinant viruses can be engineered to express foreign transgenes and have a broad tropism allowing gene expression in a wide range of host cells. They can be selected or designed for specific therapeutic goals; for example, recombinant viruses could be used to stimulate host immune response against tumor-specific antigens and therefore overcome the ability of the tumor to evade the host’s immune surveillance. Alternatively, recombinant viruses could express immunomodulatory genes which stimulate an anti-cancer immune response. Oncolytic viruses can replicate specifically in tumor cells and induce toxic effects leading to cell lysis and apoptosis. However, each of these approaches face certain difficulties that must be resolved to achieve maximum therapeutic efficacy. In this review we discuss actively developing approaches for cancer therapy based on recombinant viruses, problems that need to be overcome, and possible prospects for further development of recombinant virus based therapy.
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spelling pubmed-63164732019-01-10 Recombinant Viruses for Cancer Therapy Chulpanova, Daria S. Solovyeva, Valeriya V. Kitaeva, Kristina V. Dunham, Stephen P. Khaiboullina, Svetlana F. Rizvanov, Albert A. Biomedicines Review Recombinant viruses are novel therapeutic agents that can be utilized for treatment of various diseases, including cancers. Recombinant viruses can be engineered to express foreign transgenes and have a broad tropism allowing gene expression in a wide range of host cells. They can be selected or designed for specific therapeutic goals; for example, recombinant viruses could be used to stimulate host immune response against tumor-specific antigens and therefore overcome the ability of the tumor to evade the host’s immune surveillance. Alternatively, recombinant viruses could express immunomodulatory genes which stimulate an anti-cancer immune response. Oncolytic viruses can replicate specifically in tumor cells and induce toxic effects leading to cell lysis and apoptosis. However, each of these approaches face certain difficulties that must be resolved to achieve maximum therapeutic efficacy. In this review we discuss actively developing approaches for cancer therapy based on recombinant viruses, problems that need to be overcome, and possible prospects for further development of recombinant virus based therapy. MDPI 2018-09-25 /pmc/articles/PMC6316473/ /pubmed/30257488 http://dx.doi.org/10.3390/biomedicines6040094 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chulpanova, Daria S.
Solovyeva, Valeriya V.
Kitaeva, Kristina V.
Dunham, Stephen P.
Khaiboullina, Svetlana F.
Rizvanov, Albert A.
Recombinant Viruses for Cancer Therapy
title Recombinant Viruses for Cancer Therapy
title_full Recombinant Viruses for Cancer Therapy
title_fullStr Recombinant Viruses for Cancer Therapy
title_full_unstemmed Recombinant Viruses for Cancer Therapy
title_short Recombinant Viruses for Cancer Therapy
title_sort recombinant viruses for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316473/
https://www.ncbi.nlm.nih.gov/pubmed/30257488
http://dx.doi.org/10.3390/biomedicines6040094
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