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Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels

Recently, the construction of models for multicellular systems such as tissues has been attracting great interest. These model systems are expected to reproduce a cell communication network and provide insight into complicated functions in living systems./Such network structures have mainly been mod...

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Detalles Bibliográficos
Autores principales: Hayakawa, Masayuki, Umeyama, Satoshi, Nagai, Ken H., Onoe, Hiroaki, Takinoue, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316562/
https://www.ncbi.nlm.nih.gov/pubmed/30241312
http://dx.doi.org/10.3390/life8040038
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author Hayakawa, Masayuki
Umeyama, Satoshi
Nagai, Ken H.
Onoe, Hiroaki
Takinoue, Masahiro
author_facet Hayakawa, Masayuki
Umeyama, Satoshi
Nagai, Ken H.
Onoe, Hiroaki
Takinoue, Masahiro
author_sort Hayakawa, Masayuki
collection PubMed
description Recently, the construction of models for multicellular systems such as tissues has been attracting great interest. These model systems are expected to reproduce a cell communication network and provide insight into complicated functions in living systems./Such network structures have mainly been modelled using a droplet and a vesicle. However, in the droplet and vesicle network, there are difficulties attributed to structural instabilities due to external stimuli and perturbations. Thus, the fabrication of a network composed of a stable component such as hydrogel is desired. In this article, the construction of a stable network composed of honeycomb-shaped microhydrogels is described. We produced the microhydrogel network using a centrifugal microfluidic technique and a photosensitive polymer. In the network, densely packed honeycomb-shaped microhydrogels were observed. Additionally, we successfully controlled the degree of packing of microhydrogels in the network by changing the centrifugal force. We believe that our stable network will contribute to the study of cell communication in multicellular systems.
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spelling pubmed-63165622019-01-10 Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels Hayakawa, Masayuki Umeyama, Satoshi Nagai, Ken H. Onoe, Hiroaki Takinoue, Masahiro Life (Basel) Article Recently, the construction of models for multicellular systems such as tissues has been attracting great interest. These model systems are expected to reproduce a cell communication network and provide insight into complicated functions in living systems./Such network structures have mainly been modelled using a droplet and a vesicle. However, in the droplet and vesicle network, there are difficulties attributed to structural instabilities due to external stimuli and perturbations. Thus, the fabrication of a network composed of a stable component such as hydrogel is desired. In this article, the construction of a stable network composed of honeycomb-shaped microhydrogels is described. We produced the microhydrogel network using a centrifugal microfluidic technique and a photosensitive polymer. In the network, densely packed honeycomb-shaped microhydrogels were observed. Additionally, we successfully controlled the degree of packing of microhydrogels in the network by changing the centrifugal force. We believe that our stable network will contribute to the study of cell communication in multicellular systems. MDPI 2018-09-20 /pmc/articles/PMC6316562/ /pubmed/30241312 http://dx.doi.org/10.3390/life8040038 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hayakawa, Masayuki
Umeyama, Satoshi
Nagai, Ken H.
Onoe, Hiroaki
Takinoue, Masahiro
Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels
title Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels
title_full Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels
title_fullStr Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels
title_full_unstemmed Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels
title_short Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels
title_sort controlled construction of stable network structure composed of honeycomb-shaped microhydrogels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316562/
https://www.ncbi.nlm.nih.gov/pubmed/30241312
http://dx.doi.org/10.3390/life8040038
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