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Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging

Exercise training (ET), anabolic androgenic steroids (AAS), and aging are potential factors that affect tendon homeostasis, particularly extracellular matrix (ECM) remodeling. The goal of this review is to aggregate findings regarding the effects of resistance training (RT), AAS, and aging on tendon...

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Autores principales: Guzzoni, Vinicius, Selistre-de-Araújo, Heloisa Sobreiro, de Cássia Marqueti, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316563/
https://www.ncbi.nlm.nih.gov/pubmed/30544536
http://dx.doi.org/10.3390/cells7120251
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author Guzzoni, Vinicius
Selistre-de-Araújo, Heloisa Sobreiro
de Cássia Marqueti, Rita
author_facet Guzzoni, Vinicius
Selistre-de-Araújo, Heloisa Sobreiro
de Cássia Marqueti, Rita
author_sort Guzzoni, Vinicius
collection PubMed
description Exercise training (ET), anabolic androgenic steroids (AAS), and aging are potential factors that affect tendon homeostasis, particularly extracellular matrix (ECM) remodeling. The goal of this review is to aggregate findings regarding the effects of resistance training (RT), AAS, and aging on tendon homeostasis. Data were gathered from our studies regarding the impact of RT, AAS, and aging on the calcaneal tendon (CT) of rats. We demonstrated a series of detrimental effects of AAS and aging on functional and biomechanical parameters, including the volume density of blood vessel cells, adipose tissue cells, tendon calcification, collagen content, the regulation of the major proteins related to the metabolic/development processes of tendons, and ECM remodeling. Conversely, RT seems to mitigate age-related tendon dysfunction. Our results suggest that AAS combined with high-intensity RT exert harmful effects on ECM remodeling, and also instigate molecular and biomechanical adaptations in the CT. Moreover, we provide further information regarding the harmful effects of AAS on tendons at a transcriptional level, and demonstrate the beneficial effects of RT against the age-induced tendon adaptations of rats. Our studies might contribute in terms of clinical approaches in favor of the benefits of ET against tendinopathy conditions, and provide a warning on the harmful effects of the misuse of AAS on tendon development.
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spelling pubmed-63165632019-01-09 Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging Guzzoni, Vinicius Selistre-de-Araújo, Heloisa Sobreiro de Cássia Marqueti, Rita Cells Review Exercise training (ET), anabolic androgenic steroids (AAS), and aging are potential factors that affect tendon homeostasis, particularly extracellular matrix (ECM) remodeling. The goal of this review is to aggregate findings regarding the effects of resistance training (RT), AAS, and aging on tendon homeostasis. Data were gathered from our studies regarding the impact of RT, AAS, and aging on the calcaneal tendon (CT) of rats. We demonstrated a series of detrimental effects of AAS and aging on functional and biomechanical parameters, including the volume density of blood vessel cells, adipose tissue cells, tendon calcification, collagen content, the regulation of the major proteins related to the metabolic/development processes of tendons, and ECM remodeling. Conversely, RT seems to mitigate age-related tendon dysfunction. Our results suggest that AAS combined with high-intensity RT exert harmful effects on ECM remodeling, and also instigate molecular and biomechanical adaptations in the CT. Moreover, we provide further information regarding the harmful effects of AAS on tendons at a transcriptional level, and demonstrate the beneficial effects of RT against the age-induced tendon adaptations of rats. Our studies might contribute in terms of clinical approaches in favor of the benefits of ET against tendinopathy conditions, and provide a warning on the harmful effects of the misuse of AAS on tendon development. MDPI 2018-12-07 /pmc/articles/PMC6316563/ /pubmed/30544536 http://dx.doi.org/10.3390/cells7120251 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guzzoni, Vinicius
Selistre-de-Araújo, Heloisa Sobreiro
de Cássia Marqueti, Rita
Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging
title Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging
title_full Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging
title_fullStr Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging
title_full_unstemmed Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging
title_short Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging
title_sort tendon remodeling in response to resistance training, anabolic androgenic steroids and aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316563/
https://www.ncbi.nlm.nih.gov/pubmed/30544536
http://dx.doi.org/10.3390/cells7120251
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