The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca(2+)-Dependent Manner

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to reduce protein load and restore homeostasis, including via induction of autophagy. We used the proline analogue l-azetidine-2-carboxylic acid (AZC) to induce ER stress, and assessed...

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Detalles Bibliográficos
Autores principales: Roest, Gemma, Hesemans, Evelien, Welkenhuyzen, Kirsten, Luyten, Tomas, Engedal, Nikolai, Bultynck, Geert, Parys, Jan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316609/
https://www.ncbi.nlm.nih.gov/pubmed/30513588
http://dx.doi.org/10.3390/cells7120239

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