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A Simple and Convenient Synthesis of Unlabeled and (13)C-Labeled 3-(3-Hydroxyphenyl)-3-Hydroxypropionic Acid and Its Quantification in Human Urine Samples

An improved method to synthesize the highly abundant and biomedically important urinary metabolite 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) is reported. The modified protocol is based on an indium-mediated sonochemical Reformatsky reaction. The synthesis is a simple two-step route as oppo...

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Detalles Bibliográficos
Autores principales:	Khaniani, Yeganeh, Lipfert, Matthias, Bhattacharyya, Dipanjan, Perez Pineiro, Rolando, Zheng, Jiamin, Wishart, David S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316614/ https://www.ncbi.nlm.nih.gov/pubmed/30469313 http://dx.doi.org/10.3390/metabo8040080

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