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Local Tandem Repeat Expansion in Xist RNA as a Model for the Functionalisation of ncRNA
Xist, the master regulator of the X chromosome inactivation in mammals, is a 17 kb lncRNA that acts in cis to silence the majority of genes along the chromosome from which it is transcribed. The two key processes required for Xist RNA function, localisation in cis and recruitment of silencing factor...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316617/ https://www.ncbi.nlm.nih.gov/pubmed/30347781 http://dx.doi.org/10.3390/ncrna4040028 |