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Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization Study

Whether vitamin D insufficiency is a contributing cause of depression remains unclear. We assessed whether serum 25-hydroxyvitamin D (S-25OHD) concentrations, the clinical marker of vitamin D status, were associated with major depression using Mendelian randomization. We used summary statistics data...

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Autores principales: Michaëlsson, Karl, Melhus, Håkan, Larsson, Susanna C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316636/
https://www.ncbi.nlm.nih.gov/pubmed/30558284
http://dx.doi.org/10.3390/nu10121987
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author Michaëlsson, Karl
Melhus, Håkan
Larsson, Susanna C.
author_facet Michaëlsson, Karl
Melhus, Håkan
Larsson, Susanna C.
author_sort Michaëlsson, Karl
collection PubMed
description Whether vitamin D insufficiency is a contributing cause of depression remains unclear. We assessed whether serum 25-hydroxyvitamin D (S-25OHD) concentrations, the clinical marker of vitamin D status, were associated with major depression using Mendelian randomization. We used summary statistics data for six single-nucleotide polymorphisms significantly associated with S-25OHD concentrations in the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits (SUNLIGHT) consortium and the corresponding data for major depression (n = 59,851 cases and 113,154 controls) from the Psychiatric Genomics Consortium. Genetically predicted S-25OHD concentrations were not associated with major depression. The odds ratio per genetically predicted one standard deviation decrease in S-25OHD concentrations was 1.02 (95% confidence interval 0.97–1.08; p = 0.44). The results of this study indicate that genetically lowered S-25OHD concentrations are not associated with increased risk of developing major depression.
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spelling pubmed-63166362019-01-08 Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization Study Michaëlsson, Karl Melhus, Håkan Larsson, Susanna C. Nutrients Brief Report Whether vitamin D insufficiency is a contributing cause of depression remains unclear. We assessed whether serum 25-hydroxyvitamin D (S-25OHD) concentrations, the clinical marker of vitamin D status, were associated with major depression using Mendelian randomization. We used summary statistics data for six single-nucleotide polymorphisms significantly associated with S-25OHD concentrations in the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits (SUNLIGHT) consortium and the corresponding data for major depression (n = 59,851 cases and 113,154 controls) from the Psychiatric Genomics Consortium. Genetically predicted S-25OHD concentrations were not associated with major depression. The odds ratio per genetically predicted one standard deviation decrease in S-25OHD concentrations was 1.02 (95% confidence interval 0.97–1.08; p = 0.44). The results of this study indicate that genetically lowered S-25OHD concentrations are not associated with increased risk of developing major depression. MDPI 2018-12-15 /pmc/articles/PMC6316636/ /pubmed/30558284 http://dx.doi.org/10.3390/nu10121987 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Michaëlsson, Karl
Melhus, Håkan
Larsson, Susanna C.
Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization Study
title Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization Study
title_full Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization Study
title_fullStr Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization Study
title_full_unstemmed Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization Study
title_short Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization Study
title_sort serum 25-hydroxyvitamin d concentrations and major depression: a mendelian randomization study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316636/
https://www.ncbi.nlm.nih.gov/pubmed/30558284
http://dx.doi.org/10.3390/nu10121987
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