Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells

Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits. Mcl-1 is an anti-apoptotic protein that promotes resistance to paclitaxel in different tumors. Obatoclax, a BH3 mime...

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Detalles Bibliográficos
Autores principales: Jiménez-Guerrero, Rocío, Gasca, Jessica, Flores, M. Luz, Pérez-Valderrama, Begoña, Tejera-Parrado, Cristina, Medina, Rafael, Tortolero, María, Romero, Francisco, Japón, Miguel A., Sáez, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316685/
https://www.ncbi.nlm.nih.gov/pubmed/30563080
http://dx.doi.org/10.3390/cancers10120490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316685/
https://www.ncbi.nlm.nih.gov/pubmed/30563080
http://dx.doi.org/10.3390/cancers10120490

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