Cargando…

Systems Analysis of Transcriptomic and Proteomic Profiles Identifies Novel Regulation of Fibrotic Programs by miRNAs in Pulmonary Fibrosis Fibroblasts

Fibroblasts/myofibroblasts are the key effector cells responsible for excessive extracellular matrix (ECM) deposition and fibrosis progression in both idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc) patient lungs, thus it is critical to understand the transcriptomic and proteomic pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mullenbrock, Steven, Liu, Fei, Szak, Suzanne, Hronowski, Xiaoping, Gao, Benbo, Juhasz, Peter, Sun, Chao, Liu, Mei, McLaughlin, Helen, Xiao, Qiurong, Feghali-Bostwick, Carol, Zheng, Timothy S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316743/ https://www.ncbi.nlm.nih.gov/pubmed/30501089 http://dx.doi.org/10.3390/genes9120588

Ejemplares similares

Fibroblasts in fibrosis: novel roles and mediators
por: Kendall, Ryan T., et al.
Publicado: (2014)

IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2018)

Human Skin Culture as an Ex Vivo Model for Assessing the Fibrotic Effects of Insulin-Like Growth Factor Binding Proteins
por: Yasuoka, Hidekata, et al.
Publicado: (2008)

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro
por: Brennan, Melanie S., et al.
Publicado: (2015)

The Molecular Mechanisms of Systemic Sclerosis-Associated Lung Fibrosis
por: Mouawad, Joe E., et al.
Publicado: (2023)

Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis
por: Artlett, Carol M., et al.
Publicado: (2017)

Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis
por: Hadjicharalambous, Marina R., et al.
Publicado: (2019)

382 The Role of the IL-6-IGF-II Axis in Systemic Sclerosis-Associated Lung Fibrosis
por: Adewale, Adegboyega Timothy, et al.
Publicado: (2023)

Antifibrotic Effects of Roscovitine in Normal and Scleroderma Fibroblasts
por: Steinman, Richard A., et al.
Publicado: (2012)

Low Baseline Expression of Fibrotic Genes in an Ex Vivo Human Skin Model is a Potential Indicator of Excessive Skin Scarring
por: Mouawad, Joe E., et al.
Publicado: (2022)

IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF
por: Su, Yunyun, et al.
Publicado: (2015)

Insulin-Like Growth Factor Binding Proteins-3 and -5: Central Mediators of Fibrosis and Promising New Therapeutic Targets
por: Veraldi, Kristen L, et al.
Publicado: (2012)

The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis
por: Yasuoka, Hidekata, et al.
Publicado: (2014)

Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis
por: Aida-Yasuoka, Keiko, et al.
Publicado: (2013)

Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2021)

PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1
por: Takamura, Naoko, et al.
Publicado: (2021)

Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5
por: Yamaguchi, Yukie, et al.
Publicado: (2011)

Elucidating the cellular mechanism for E2-induced dermal fibrosis
por: Baker Frost, DeAnna, et al.
Publicado: (2021)

A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition
por: Watanabe, Tomoya, et al.
Publicado: (2019)

Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is K(Ca)3.1-dependent
por: Roach, Katy M, et al.
Publicado: (2014)

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
por: Garrett, Sara M., et al.
Publicado: (2019)

First Characterization of the Transcriptome of Lung Fibroblasts of SSc Patients and Healthy Donors of African Ancestry
por: Renaud, Ludivine, et al.
Publicado: (2023)

Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis
por: Renaud, Ludivine, et al.
Publicado: (2020)

Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts
por: Hadjicharalambous, Marina R., et al.
Publicado: (2018)

The Role of SOX9 in IGF-II-Mediated Pulmonary Fibrosis
por: Waldrep, Kristy M., et al.
Publicado: (2023)

The K(+) Channel K(Ca)3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis
por: Roach, Katy Morgan, et al.
Publicado: (2013)

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis
por: Coward, William R., et al.
Publicado: (2014)

Periostin plays a critical role in the cell cycle in lung fibroblasts
por: Yoshihara, Tomohito, et al.
Publicado: (2020)

Correction: The K(+) Channel K(Ca)3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis
por: Roach, Katy M, et al.
Publicado: (2014)

2027 The role of lysyl oxidase in systemic sclerosis-associated lung fibrosis
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2018)

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts
por: Shi-wen, Xu, et al.
Publicado: (2009)

Proteomics approaches to fibrotic disorders
por: Gucek, Marjan
Publicado: (2012)

T Cells in Fibrosis and Fibrotic Diseases
por: Zhang, Mengjuan, et al.
Publicado: (2020)

Proteomics identifies differences in fibrotic potential of extracellular vesicles from human tendon and muscle fibroblasts
por: Yeung, Ching-Yan Chloé, et al.
Publicado: (2020)

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
por: Wang, Xiao Mei, et al.
Publicado: (2006)

Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis
por: Hostettler, Katrin E, et al.
Publicado: (2014)

Induction of a Th17 Phenotype in Human Skin—A Mimic of Dermal Inflammatory Diseases
por: Garrett, Sara M., et al.
Publicado: (2019)

Therapeutic Challenges And Advances In The Management Of Systemic Sclerosis-Related Pulmonary Arterial Hypertension (SSc-PAH)
por: Argula, Rahul G, et al.
Publicado: (2019)

Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease
por: Shaw, Tanya J, et al.
Publicado: (2020)

Genetics of systemic sclerosis: recent advances
por: Ramos, Paula S., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5ot8l0qnf280smn5du91t2s9ug