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N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review
N(6)-methyladenosine (m(6)A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m(6...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316766/ https://www.ncbi.nlm.nih.gov/pubmed/30513695 http://dx.doi.org/10.3390/genes9120596 |
Sumario: | N(6)-methyladenosine (m(6)A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m(6)A has peaked again. Similar to animal mRNAs, plant mRNAs are also m(6)A methylated, within a specific sequence motif which is conserved across these kingdoms. m(6)A has been found to be pivotal for plant development and necessary for processes ranging from seed germination to floral development. A wide range of proteins involved in methylation of adenosine have been identified alongside proteins that remove or identify m(6)A. This review aims to put together the current knowledge regarding m(6)A in Arabidopsis thaliana. |
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