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N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review

N(6)-methyladenosine (m(6)A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m(6...

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Autores principales: Bhat, Susheel Sagar, Bielewicz, Dawid, Jarmolowski, Artur, Szweykowska-Kulinska, Zofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316766/
https://www.ncbi.nlm.nih.gov/pubmed/30513695
http://dx.doi.org/10.3390/genes9120596
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author Bhat, Susheel Sagar
Bielewicz, Dawid
Jarmolowski, Artur
Szweykowska-Kulinska, Zofia
author_facet Bhat, Susheel Sagar
Bielewicz, Dawid
Jarmolowski, Artur
Szweykowska-Kulinska, Zofia
author_sort Bhat, Susheel Sagar
collection PubMed
description N(6)-methyladenosine (m(6)A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m(6)A has peaked again. Similar to animal mRNAs, plant mRNAs are also m(6)A methylated, within a specific sequence motif which is conserved across these kingdoms. m(6)A has been found to be pivotal for plant development and necessary for processes ranging from seed germination to floral development. A wide range of proteins involved in methylation of adenosine have been identified alongside proteins that remove or identify m(6)A. This review aims to put together the current knowledge regarding m(6)A in Arabidopsis thaliana.
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spelling pubmed-63167662019-01-09 N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review Bhat, Susheel Sagar Bielewicz, Dawid Jarmolowski, Artur Szweykowska-Kulinska, Zofia Genes (Basel) Review N(6)-methyladenosine (m(6)A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m(6)A has peaked again. Similar to animal mRNAs, plant mRNAs are also m(6)A methylated, within a specific sequence motif which is conserved across these kingdoms. m(6)A has been found to be pivotal for plant development and necessary for processes ranging from seed germination to floral development. A wide range of proteins involved in methylation of adenosine have been identified alongside proteins that remove or identify m(6)A. This review aims to put together the current knowledge regarding m(6)A in Arabidopsis thaliana. MDPI 2018-11-30 /pmc/articles/PMC6316766/ /pubmed/30513695 http://dx.doi.org/10.3390/genes9120596 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bhat, Susheel Sagar
Bielewicz, Dawid
Jarmolowski, Artur
Szweykowska-Kulinska, Zofia
N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review
title N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review
title_full N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review
title_fullStr N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review
title_full_unstemmed N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review
title_short N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review
title_sort n(6)-methyladenosine (m(6)a): revisiting the old with focus on new, an arabidopsis thaliana centered review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316766/
https://www.ncbi.nlm.nih.gov/pubmed/30513695
http://dx.doi.org/10.3390/genes9120596
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