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N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review
N(6)-methyladenosine (m(6)A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m(6...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316766/ https://www.ncbi.nlm.nih.gov/pubmed/30513695 http://dx.doi.org/10.3390/genes9120596 |
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author | Bhat, Susheel Sagar Bielewicz, Dawid Jarmolowski, Artur Szweykowska-Kulinska, Zofia |
author_facet | Bhat, Susheel Sagar Bielewicz, Dawid Jarmolowski, Artur Szweykowska-Kulinska, Zofia |
author_sort | Bhat, Susheel Sagar |
collection | PubMed |
description | N(6)-methyladenosine (m(6)A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m(6)A has peaked again. Similar to animal mRNAs, plant mRNAs are also m(6)A methylated, within a specific sequence motif which is conserved across these kingdoms. m(6)A has been found to be pivotal for plant development and necessary for processes ranging from seed germination to floral development. A wide range of proteins involved in methylation of adenosine have been identified alongside proteins that remove or identify m(6)A. This review aims to put together the current knowledge regarding m(6)A in Arabidopsis thaliana. |
format | Online Article Text |
id | pubmed-6316766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63167662019-01-09 N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review Bhat, Susheel Sagar Bielewicz, Dawid Jarmolowski, Artur Szweykowska-Kulinska, Zofia Genes (Basel) Review N(6)-methyladenosine (m(6)A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m(6)A has peaked again. Similar to animal mRNAs, plant mRNAs are also m(6)A methylated, within a specific sequence motif which is conserved across these kingdoms. m(6)A has been found to be pivotal for plant development and necessary for processes ranging from seed germination to floral development. A wide range of proteins involved in methylation of adenosine have been identified alongside proteins that remove or identify m(6)A. This review aims to put together the current knowledge regarding m(6)A in Arabidopsis thaliana. MDPI 2018-11-30 /pmc/articles/PMC6316766/ /pubmed/30513695 http://dx.doi.org/10.3390/genes9120596 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bhat, Susheel Sagar Bielewicz, Dawid Jarmolowski, Artur Szweykowska-Kulinska, Zofia N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review |
title | N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review |
title_full | N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review |
title_fullStr | N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review |
title_full_unstemmed | N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review |
title_short | N(6)-methyladenosine (m(6)A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review |
title_sort | n(6)-methyladenosine (m(6)a): revisiting the old with focus on new, an arabidopsis thaliana centered review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316766/ https://www.ncbi.nlm.nih.gov/pubmed/30513695 http://dx.doi.org/10.3390/genes9120596 |
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