Activation of Polyamine Catabolism by N(1),N(11)-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype

Tumorigenesis is accompanied by the metabolic adaptation of cells to support enhanced proliferation rates and to optimize tumor persistence and amplification within the local microenvironment. In particular, cancer cells exhibit elevated levels of biogenic polyamines. Inhibitors of polyamine biosynt...

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Detalles Bibliográficos
Autores principales: Ivanova, Olga N., Snezhkina, Anastasiya V., Krasnov, George S., Valuev-Elliston, Vladimir T., Khomich, Olga A., Khomutov, Alexey R., Keinanen, Tuomo A., Alhonen, Leena, Bartosch, Birke, Kudryavtseva, Anna V., Kochetkov, Sergey N., Ivanov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316793/
https://www.ncbi.nlm.nih.gov/pubmed/30567412
http://dx.doi.org/10.3390/cells7120275

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