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Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins
Among all new nanomaterials, metal nanoclusters (NCs) have attracted special attention due to their interesting optical properties, among others. Metal NCs have been recently studied and used as sensors for different analytes. However, there is a need to explore the potential of these new sensors in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316832/ https://www.ncbi.nlm.nih.gov/pubmed/30445749 http://dx.doi.org/10.3390/bios8040110 |
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author | Aires, Antonio Lopez-Martinez, Elena Cortajarena, Aitziber L. |
author_facet | Aires, Antonio Lopez-Martinez, Elena Cortajarena, Aitziber L. |
author_sort | Aires, Antonio |
collection | PubMed |
description | Among all new nanomaterials, metal nanoclusters (NCs) have attracted special attention due to their interesting optical properties, among others. Metal NCs have been recently studied and used as sensors for different analytes. However, there is a need to explore the potential of these new sensors in a systematic manner and to develop new systems to broaden the possibilities that sensing offers to the industry. In this work, we show the potential use of repeat protein scaffolds as versatile templates for the synthesis and stabilization of various metal NCs, specifically Au, Ag, and CuNCs. The resulting protein-metal NCs hybrids are evaluated as sensors for different stimuli such as temperature, ions, or reactive oxygen species (ROS). Among the three protein-metal NCs, all performed nicely as temperature sensors, AuNCs responded to metal ions, and AgNCs were able to detect ROS. |
format | Online Article Text |
id | pubmed-6316832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63168322019-01-09 Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins Aires, Antonio Lopez-Martinez, Elena Cortajarena, Aitziber L. Biosensors (Basel) Article Among all new nanomaterials, metal nanoclusters (NCs) have attracted special attention due to their interesting optical properties, among others. Metal NCs have been recently studied and used as sensors for different analytes. However, there is a need to explore the potential of these new sensors in a systematic manner and to develop new systems to broaden the possibilities that sensing offers to the industry. In this work, we show the potential use of repeat protein scaffolds as versatile templates for the synthesis and stabilization of various metal NCs, specifically Au, Ag, and CuNCs. The resulting protein-metal NCs hybrids are evaluated as sensors for different stimuli such as temperature, ions, or reactive oxygen species (ROS). Among the three protein-metal NCs, all performed nicely as temperature sensors, AuNCs responded to metal ions, and AgNCs were able to detect ROS. MDPI 2018-11-15 /pmc/articles/PMC6316832/ /pubmed/30445749 http://dx.doi.org/10.3390/bios8040110 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aires, Antonio Lopez-Martinez, Elena Cortajarena, Aitziber L. Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins |
title | Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins |
title_full | Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins |
title_fullStr | Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins |
title_full_unstemmed | Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins |
title_short | Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins |
title_sort | sensors based on metal nanoclusters stabilized on designed proteins |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316832/ https://www.ncbi.nlm.nih.gov/pubmed/30445749 http://dx.doi.org/10.3390/bios8040110 |
work_keys_str_mv | AT airesantonio sensorsbasedonmetalnanoclustersstabilizedondesignedproteins AT lopezmartinezelena sensorsbasedonmetalnanoclustersstabilizedondesignedproteins AT cortajarenaaitziberl sensorsbasedonmetalnanoclustersstabilizedondesignedproteins |