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Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins

Among all new nanomaterials, metal nanoclusters (NCs) have attracted special attention due to their interesting optical properties, among others. Metal NCs have been recently studied and used as sensors for different analytes. However, there is a need to explore the potential of these new sensors in...

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Detalles Bibliográficos
Autores principales: Aires, Antonio, Lopez-Martinez, Elena, Cortajarena, Aitziber L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316832/
https://www.ncbi.nlm.nih.gov/pubmed/30445749
http://dx.doi.org/10.3390/bios8040110
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author Aires, Antonio
Lopez-Martinez, Elena
Cortajarena, Aitziber L.
author_facet Aires, Antonio
Lopez-Martinez, Elena
Cortajarena, Aitziber L.
author_sort Aires, Antonio
collection PubMed
description Among all new nanomaterials, metal nanoclusters (NCs) have attracted special attention due to their interesting optical properties, among others. Metal NCs have been recently studied and used as sensors for different analytes. However, there is a need to explore the potential of these new sensors in a systematic manner and to develop new systems to broaden the possibilities that sensing offers to the industry. In this work, we show the potential use of repeat protein scaffolds as versatile templates for the synthesis and stabilization of various metal NCs, specifically Au, Ag, and CuNCs. The resulting protein-metal NCs hybrids are evaluated as sensors for different stimuli such as temperature, ions, or reactive oxygen species (ROS). Among the three protein-metal NCs, all performed nicely as temperature sensors, AuNCs responded to metal ions, and AgNCs were able to detect ROS.
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spelling pubmed-63168322019-01-09 Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins Aires, Antonio Lopez-Martinez, Elena Cortajarena, Aitziber L. Biosensors (Basel) Article Among all new nanomaterials, metal nanoclusters (NCs) have attracted special attention due to their interesting optical properties, among others. Metal NCs have been recently studied and used as sensors for different analytes. However, there is a need to explore the potential of these new sensors in a systematic manner and to develop new systems to broaden the possibilities that sensing offers to the industry. In this work, we show the potential use of repeat protein scaffolds as versatile templates for the synthesis and stabilization of various metal NCs, specifically Au, Ag, and CuNCs. The resulting protein-metal NCs hybrids are evaluated as sensors for different stimuli such as temperature, ions, or reactive oxygen species (ROS). Among the three protein-metal NCs, all performed nicely as temperature sensors, AuNCs responded to metal ions, and AgNCs were able to detect ROS. MDPI 2018-11-15 /pmc/articles/PMC6316832/ /pubmed/30445749 http://dx.doi.org/10.3390/bios8040110 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aires, Antonio
Lopez-Martinez, Elena
Cortajarena, Aitziber L.
Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins
title Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins
title_full Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins
title_fullStr Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins
title_full_unstemmed Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins
title_short Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins
title_sort sensors based on metal nanoclusters stabilized on designed proteins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316832/
https://www.ncbi.nlm.nih.gov/pubmed/30445749
http://dx.doi.org/10.3390/bios8040110
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