Cargando…

Use of Germline Genetic Variability for Prediction of Chemoresistance and Prognosis of Breast Cancer Patients

The aim of our study was to set up a panel for targeted sequencing of chemoresistance genes and the main transcription factors driving their expression and to evaluate their predictive and prognostic value in breast cancer patients. Coding and regulatory regions of 509 genes, selected from PharmGKB...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hlavac, Viktor, Kovacova, Maria, Elsnerova, Katerina, Brynychova, Veronika, Kozevnikovova, Renata, Raus, Karel, Kopeckova, Katerina, Mestakova, Sona, Vrana, David, Gatek, Jiri, Ostasov, Pavel, Vaclavikova, Radka, Soucek, Pavel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316878/ https://www.ncbi.nlm.nih.gov/pubmed/30545124 http://dx.doi.org/10.3390/cancers10120511

Ejemplares similares

Role of Genetic Variation in Cytochromes P450 in Breast Cancer Prognosis and Therapy Response
por: Hlaváč, Viktor, et al.
Publicado: (2021)

Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response
por: Hlaváč, Viktor, et al.
Publicado: (2020)

Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early‐stage luminal breast cancer
por: Holý, Petr, et al.
Publicado: (2023)

The Role of Cytochromes P450 and Aldo-Keto Reductases in Prognosis of Breast Carcinoma Patients
por: Hlaváč, Viktor, et al.
Publicado: (2014)

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer
por: Vrana, David, et al.
Publicado: (2018)

Non-Coding Polymorphisms in Nucleotide Binding Domain 1 in ABCC1 Gene Associate with Transcript Level and Survival of Patients with Breast Cancer
por: Kunická, Tereza, et al.
Publicado: (2014)

Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases
por: Hlavac, Viktor, et al.
Publicado: (2020)

Association of ABC gene profiles with time to progression and resistance in ovarian cancer revealed by bioinformatics analyses
por: Seborova, Karolina, et al.
Publicado: (2019)

Gene Expression Profiling Reveals Novel Candidate Markers of Ovarian Carcinoma Intraperitoneal Metastasis
por: Elsnerova, Katerina, et al.
Publicado: (2017)

Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes
por: Vymetalkova, Veronika, et al.
Publicado: (2015)

Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapy
por: Hlaváč, Viktor, et al.
Publicado: (2022)

Non-Coding RNAs as Biomarkers of Tumor Progression and Metastatic Spread in Epithelial Ovarian Cancer
por: Seborova, Karolina, et al.
Publicado: (2021)

5′ Untranslated Region Elements Show High Abundance and Great Variability in Homologous ABCA Subfamily Genes
por: Dvorak, Pavel, et al.
Publicado: (2020)

Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450
por: Hlaváč, Viktor, et al.
Publicado: (2020)

Laser Capture Microdissection: A Gear for Pancreatic Cancer Research
por: Rao, Bhavana Hemantha, et al.
Publicado: (2022)

An Improved in Vivo Deuterium Labeling Method for Measuring the Biosynthetic Rate of Cytokinins
por: Tarkowski, Petr, et al.
Publicado: (2010)

Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy
por: Seborova, Karolina, et al.
Publicado: (2022)

Downregulation of ABC Transporters in Non-neoplastic Tissues Confers Better Prognosis for Pancreatic and Colorectal Cancer Patients
por: Dvorak, Pavel, et al.
Publicado: (2017)

Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome
por: Lemstrova, Radmila, et al.
Publicado: (2017)

Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases
por: Heczko, Lucie, et al.
Publicado: (2023)

Association of lncRNA and transcriptome intersections with response to targeted therapy in metastatic renal cell carcinoma
por: Tesarova, Tereza, et al.
Publicado: (2023)

Internal mammary lymph node management – further direction
por: Vrana, D, et al.
Publicado: (2017)

Role of N-Cadherin in Epithelial-to-Mesenchymal Transition and Chemosensitivity of Colon Carcinoma Cells
por: Skarkova, Veronika, et al.
Publicado: (2022)

Single-Nucleotide Polymorphisms in MICA and MICB Genes Could Play a Role in the Outcome in AML Patients after HSCT
por: Machuldova, Alena, et al.
Publicado: (2021)

Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial
por: Žatecký, Jan, et al.
Publicado: (2023)

Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer
por: Hanicinec, Vojtech, et al.
Publicado: (2021)

The Expression Profile of MicroRNAs in Small and Large Abdominal Aortic Aneurysms
por: Černá, Václava, et al.
Publicado: (2019)

Editorial: Strategies in overcoming the chemoresistance in colorectal cancer
por: Vodenkova, Sona, et al.
Publicado: (2023)

Effect of Hot Isostatic Pressing on Porosity and Mechanical Properties of 316 L Stainless Steel Prepared by the Selective Laser Melting Method
por: Cegan, Tomas, et al.
Publicado: (2020)

Germline mutation in the TP53 gene in uveal melanoma
por: Hajkova, Nikola, et al.
Publicado: (2018)

Imaging plant germline differentiation within Arabidopsis flowers by light sheet microscopy
por: Valuchova, Sona, et al.
Publicado: (2020)

Interferon‐regulated suprabasin is essential for stress‐induced stem‐like cell conversion and therapy resistance of human malignancies
por: Hubackova, Sona, et al.
Publicado: (2019)

Palladium nanoparticles on InP for hydrogen detection
por: Cernohorsky, Ondrej, et al.
Publicado: (2011)

Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin Lymphoma
por: Havranek, Ondrej, et al.
Publicado: (2015)

Exacerbation of substrate toxicity by IPTG in Escherichia coli BL21(DE3) carrying a synthetic metabolic pathway
por: Dvorak, Pavel, et al.
Publicado: (2015)

Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model
por: Seborova, Karolina, et al.
Publicado: (2022)

Identification of Bacterial Protein Interaction Partners Points to New Intracellular Functions of Francisella tularensis Glyceraldehyde-3-Phosphate Dehydrogenase
por: Kopeckova, Monika, et al.
Publicado: (2020)

Virtual Interactomics of Proteins from Biochemical Standpoint
por: Kubrycht, Jaroslav, et al.
Publicado: (2012)

Antioxidant, Anti-Inflammatory, and Multidrug Resistance Modulation Activity of Silychristin Derivatives
por: Viktorová, Jitka, et al.
Publicado: (2019)

Dynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Study
por: Dekojová, Tereza, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_u8gkoccq0j1ifi3qkf7tehl72q