pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain

Prostate apoptosis response-4 (Par-4) is a 38 kDa largely intrinsically disordered tumor suppressor protein that functions in cancer cell apoptosis. Par-4 down-regulation is often observed in cancer while up-regulation is characteristic of neurodegenerative conditions such as Alzheimer’s disease. Cl...

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Detalles Bibliográficos
Autores principales: Clark, Andrea M., Ponniah, Komala, Warden, Meghan S., Raitt, Emily M., Yawn, Andrea C., Pascal, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316887/
https://www.ncbi.nlm.nih.gov/pubmed/30518159
http://dx.doi.org/10.3390/biom8040162

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