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RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases
In recent years, the ring finger protein 213 gene (RNF213) has gradually attracted attention, mainly because it has been found that RNF213 c.14429 G>A is associated with moyamoya disease (MMD) in East Asian populations. Recent studies have revealed that RFN213 is not only associated with MMD but...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317084/ https://www.ncbi.nlm.nih.gov/pubmed/30671466 http://dx.doi.org/10.1155/2018/6359174 |
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author | Lin, Jing Sheng, Wenli |
author_facet | Lin, Jing Sheng, Wenli |
author_sort | Lin, Jing |
collection | PubMed |
description | In recent years, the ring finger protein 213 gene (RNF213) has gradually attracted attention, mainly because it has been found that RNF213 c.14429 G>A is associated with moyamoya disease (MMD) in East Asian populations. Recent studies have revealed that RFN213 is not only associated with MMD but is also connected with intracranial major artery stenosis/occlusion (ICASO) and intracranial aneurysm (IA). However, only the relationship between RNF213 c.14429 G>A and ICASO has been confirmed, and whether RNF213 has other mutations related to ICASO remains unclear. RNF213 and IA are currently only confirmed to be correlated in French-Canadian Population and no correlation has been found in the Japanese population. This review summarizes the advances in the associations between RNF213 and different cerebrovascular diseases and highlights that variant diversity of RNF213 may predispose distinct populations to dissimilar cerebrovascular diseases. |
format | Online Article Text |
id | pubmed-6317084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63170842019-01-22 RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases Lin, Jing Sheng, Wenli Biomed Res Int Review Article In recent years, the ring finger protein 213 gene (RNF213) has gradually attracted attention, mainly because it has been found that RNF213 c.14429 G>A is associated with moyamoya disease (MMD) in East Asian populations. Recent studies have revealed that RFN213 is not only associated with MMD but is also connected with intracranial major artery stenosis/occlusion (ICASO) and intracranial aneurysm (IA). However, only the relationship between RNF213 c.14429 G>A and ICASO has been confirmed, and whether RNF213 has other mutations related to ICASO remains unclear. RNF213 and IA are currently only confirmed to be correlated in French-Canadian Population and no correlation has been found in the Japanese population. This review summarizes the advances in the associations between RNF213 and different cerebrovascular diseases and highlights that variant diversity of RNF213 may predispose distinct populations to dissimilar cerebrovascular diseases. Hindawi 2018-12-20 /pmc/articles/PMC6317084/ /pubmed/30671466 http://dx.doi.org/10.1155/2018/6359174 Text en Copyright © 2018 Jing Lin and Wenli Sheng. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lin, Jing Sheng, Wenli RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases |
title | RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases |
title_full | RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases |
title_fullStr | RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases |
title_full_unstemmed | RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases |
title_short | RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases |
title_sort | rnf213 variant diversity predisposes distinct populations to dissimilar cerebrovascular diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317084/ https://www.ncbi.nlm.nih.gov/pubmed/30671466 http://dx.doi.org/10.1155/2018/6359174 |
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