Cargando…

RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases

In recent years, the ring finger protein 213 gene (RNF213) has gradually attracted attention, mainly because it has been found that RNF213 c.14429 G>A is associated with moyamoya disease (MMD) in East Asian populations. Recent studies have revealed that RFN213 is not only associated with MMD but...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Jing, Sheng, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317084/
https://www.ncbi.nlm.nih.gov/pubmed/30671466
http://dx.doi.org/10.1155/2018/6359174
_version_ 1783384678242189312
author Lin, Jing
Sheng, Wenli
author_facet Lin, Jing
Sheng, Wenli
author_sort Lin, Jing
collection PubMed
description In recent years, the ring finger protein 213 gene (RNF213) has gradually attracted attention, mainly because it has been found that RNF213 c.14429 G>A is associated with moyamoya disease (MMD) in East Asian populations. Recent studies have revealed that RFN213 is not only associated with MMD but is also connected with intracranial major artery stenosis/occlusion (ICASO) and intracranial aneurysm (IA). However, only the relationship between RNF213 c.14429 G>A and ICASO has been confirmed, and whether RNF213 has other mutations related to ICASO remains unclear. RNF213 and IA are currently only confirmed to be correlated in French-Canadian Population and no correlation has been found in the Japanese population. This review summarizes the advances in the associations between RNF213 and different cerebrovascular diseases and highlights that variant diversity of RNF213 may predispose distinct populations to dissimilar cerebrovascular diseases.
format Online
Article
Text
id pubmed-6317084
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-63170842019-01-22 RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases Lin, Jing Sheng, Wenli Biomed Res Int Review Article In recent years, the ring finger protein 213 gene (RNF213) has gradually attracted attention, mainly because it has been found that RNF213 c.14429 G>A is associated with moyamoya disease (MMD) in East Asian populations. Recent studies have revealed that RFN213 is not only associated with MMD but is also connected with intracranial major artery stenosis/occlusion (ICASO) and intracranial aneurysm (IA). However, only the relationship between RNF213 c.14429 G>A and ICASO has been confirmed, and whether RNF213 has other mutations related to ICASO remains unclear. RNF213 and IA are currently only confirmed to be correlated in French-Canadian Population and no correlation has been found in the Japanese population. This review summarizes the advances in the associations between RNF213 and different cerebrovascular diseases and highlights that variant diversity of RNF213 may predispose distinct populations to dissimilar cerebrovascular diseases. Hindawi 2018-12-20 /pmc/articles/PMC6317084/ /pubmed/30671466 http://dx.doi.org/10.1155/2018/6359174 Text en Copyright © 2018 Jing Lin and Wenli Sheng. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lin, Jing
Sheng, Wenli
RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases
title RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases
title_full RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases
title_fullStr RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases
title_full_unstemmed RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases
title_short RNF213 Variant Diversity Predisposes Distinct Populations to Dissimilar Cerebrovascular Diseases
title_sort rnf213 variant diversity predisposes distinct populations to dissimilar cerebrovascular diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317084/
https://www.ncbi.nlm.nih.gov/pubmed/30671466
http://dx.doi.org/10.1155/2018/6359174
work_keys_str_mv AT linjing rnf213variantdiversitypredisposesdistinctpopulationstodissimilarcerebrovasculardiseases
AT shengwenli rnf213variantdiversitypredisposesdistinctpopulationstodissimilarcerebrovasculardiseases