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Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization

BACKGROUND: The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis. In interphase cells, microtubules play an important role in the delivery of proteins to su...

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Detalles Bibliográficos
Autores principales:	van Vuuren, Rustelle Janse, Botes, Mandie, Jurgens, Tamarin, Joubert, Anna Margaretha, van den Bout, Iman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317210/ https://www.ncbi.nlm.nih.gov/pubmed/30622437 http://dx.doi.org/10.1186/s12935-018-0719-4

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