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STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1
BACKGROUND: The PI3K/Akt and the STAT3 pathways are functionally associated in many tumor types. Both in vitro and in vivo studies have revealed that either biochemical or genetic manipulation of the STAT3 pathway activity induce changes in the same direction in Akt activity. However, the implicated...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317239/ https://www.ncbi.nlm.nih.gov/pubmed/30622697 http://dx.doi.org/10.1186/s13578-018-0265-8 |