The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 c...

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Detalles Bibliográficos
Autores principales: Repana, Dimitra, Nulsen, Joel, Dressler, Lisa, Bortolomeazzi, Michele, Venkata, Santhilata Kuppili, Tourna, Aikaterini, Yakovleva, Anna, Palmieri, Tommaso, Ciccarelli, Francesca D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Database
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317252/
https://www.ncbi.nlm.nih.gov/pubmed/30606230
http://dx.doi.org/10.1186/s13059-018-1612-0
Descripción
Sumario:The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 cancer types from 34,905 cancer donors and multiple primary sites. This represents a more than 1.5-fold content increase compared to the previous version. NCG also annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, and protein function and essentiality. NCG is accessible at http://ncg.kcl.ac.uk/. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13059-018-1612-0) contains supplementary material, which is available to authorized users.

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