Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination

Numerous DNA repair and signaling proteins function at DNA damage sites to protect the genome. Here, we show that fusion of the promiscuous biotin ligase BirA(R118G) with RAD18 leads to localized protein biotinylation at DNA damage sites, allowing identification of ZPET (zinc finger protein proximal...

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Detalles Bibliográficos
Autores principales: Moquin, David M., Genois, Marie-Michelle, Zhang, Jia-Min, Ouyang, Jian, Yadav, Tribhuwan, Buisson, Rémi, Yazinski, Stephanie A., Tan, Jun, Boukhali, Myriam, Gagné, Jean-Philippe, Poirier, Guy G., Lan, Li, Haas, Wilhelm, Zou, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317314/
https://www.ncbi.nlm.nih.gov/pubmed/30567999
http://dx.doi.org/10.1101/gad.315978.118

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