Cargando…
Molecular regulation of peripheral B cells and their progeny in immunity
Mature B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutionary fitness of mammals. Adaptive lymphocyte function requires an initially naïve cell to proliferate extensively and its progeny to have the capacity to assume a variety of fates. These include eith...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317321/ https://www.ncbi.nlm.nih.gov/pubmed/30602439 http://dx.doi.org/10.1101/gad.320192.118 |
_version_ | 1783384732176744448 |
---|---|
author | Boothby, Mark R. Hodges, Emily Thomas, James W. |
author_facet | Boothby, Mark R. Hodges, Emily Thomas, James W. |
author_sort | Boothby, Mark R. |
collection | PubMed |
description | Mature B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutionary fitness of mammals. Adaptive lymphocyte function requires an initially naïve cell to proliferate extensively and its progeny to have the capacity to assume a variety of fates. These include either terminal differentiation (the long-lived plasma cell) or metastable transcriptional reprogramming (germinal center and memory B cells). In this review, we focus principally on the regulation of differentiation and functional diversification of the “B2” subset. An overview is combined with an account of more recent advances, including initial work on mechanisms that eliminate DNA methylation and potential links between intracellular metabolites and chromatin editing. |
format | Online Article Text |
id | pubmed-6317321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63173212019-07-01 Molecular regulation of peripheral B cells and their progeny in immunity Boothby, Mark R. Hodges, Emily Thomas, James W. Genes Dev Review Mature B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutionary fitness of mammals. Adaptive lymphocyte function requires an initially naïve cell to proliferate extensively and its progeny to have the capacity to assume a variety of fates. These include either terminal differentiation (the long-lived plasma cell) or metastable transcriptional reprogramming (germinal center and memory B cells). In this review, we focus principally on the regulation of differentiation and functional diversification of the “B2” subset. An overview is combined with an account of more recent advances, including initial work on mechanisms that eliminate DNA methylation and potential links between intracellular metabolites and chromatin editing. Cold Spring Harbor Laboratory Press 2019-01-01 /pmc/articles/PMC6317321/ /pubmed/30602439 http://dx.doi.org/10.1101/gad.320192.118 Text en © 2019 Boothby et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Boothby, Mark R. Hodges, Emily Thomas, James W. Molecular regulation of peripheral B cells and their progeny in immunity |
title | Molecular regulation of peripheral B cells and their progeny in immunity |
title_full | Molecular regulation of peripheral B cells and their progeny in immunity |
title_fullStr | Molecular regulation of peripheral B cells and their progeny in immunity |
title_full_unstemmed | Molecular regulation of peripheral B cells and their progeny in immunity |
title_short | Molecular regulation of peripheral B cells and their progeny in immunity |
title_sort | molecular regulation of peripheral b cells and their progeny in immunity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317321/ https://www.ncbi.nlm.nih.gov/pubmed/30602439 http://dx.doi.org/10.1101/gad.320192.118 |
work_keys_str_mv | AT boothbymarkr molecularregulationofperipheralbcellsandtheirprogenyinimmunity AT hodgesemily molecularregulationofperipheralbcellsandtheirprogenyinimmunity AT thomasjamesw molecularregulationofperipheralbcellsandtheirprogenyinimmunity |