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Molecular regulation of peripheral B cells and their progeny in immunity

Mature B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutionary fitness of mammals. Adaptive lymphocyte function requires an initially naïve cell to proliferate extensively and its progeny to have the capacity to assume a variety of fates. These include eith...

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Detalles Bibliográficos
Autores principales: Boothby, Mark R., Hodges, Emily, Thomas, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317321/
https://www.ncbi.nlm.nih.gov/pubmed/30602439
http://dx.doi.org/10.1101/gad.320192.118
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author Boothby, Mark R.
Hodges, Emily
Thomas, James W.
author_facet Boothby, Mark R.
Hodges, Emily
Thomas, James W.
author_sort Boothby, Mark R.
collection PubMed
description Mature B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutionary fitness of mammals. Adaptive lymphocyte function requires an initially naïve cell to proliferate extensively and its progeny to have the capacity to assume a variety of fates. These include either terminal differentiation (the long-lived plasma cell) or metastable transcriptional reprogramming (germinal center and memory B cells). In this review, we focus principally on the regulation of differentiation and functional diversification of the “B2” subset. An overview is combined with an account of more recent advances, including initial work on mechanisms that eliminate DNA methylation and potential links between intracellular metabolites and chromatin editing.
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spelling pubmed-63173212019-07-01 Molecular regulation of peripheral B cells and their progeny in immunity Boothby, Mark R. Hodges, Emily Thomas, James W. Genes Dev Review Mature B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutionary fitness of mammals. Adaptive lymphocyte function requires an initially naïve cell to proliferate extensively and its progeny to have the capacity to assume a variety of fates. These include either terminal differentiation (the long-lived plasma cell) or metastable transcriptional reprogramming (germinal center and memory B cells). In this review, we focus principally on the regulation of differentiation and functional diversification of the “B2” subset. An overview is combined with an account of more recent advances, including initial work on mechanisms that eliminate DNA methylation and potential links between intracellular metabolites and chromatin editing. Cold Spring Harbor Laboratory Press 2019-01-01 /pmc/articles/PMC6317321/ /pubmed/30602439 http://dx.doi.org/10.1101/gad.320192.118 Text en © 2019 Boothby et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Boothby, Mark R.
Hodges, Emily
Thomas, James W.
Molecular regulation of peripheral B cells and their progeny in immunity
title Molecular regulation of peripheral B cells and their progeny in immunity
title_full Molecular regulation of peripheral B cells and their progeny in immunity
title_fullStr Molecular regulation of peripheral B cells and their progeny in immunity
title_full_unstemmed Molecular regulation of peripheral B cells and their progeny in immunity
title_short Molecular regulation of peripheral B cells and their progeny in immunity
title_sort molecular regulation of peripheral b cells and their progeny in immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317321/
https://www.ncbi.nlm.nih.gov/pubmed/30602439
http://dx.doi.org/10.1101/gad.320192.118
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