Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia

Chromosomal translocations of the Mixed-lineage leukemia 1 (MLL1) gene generate MLL chimeras that drive the pathogenesis of acute myeloid and lymphoid leukemia. The untranslocated MLL1 is a substrate for proteolytic cleavage by the endopeptidase threonine aspartase 1 (taspase1); however, the biologi...

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Detalles Bibliográficos
Autores principales: Zhao, Zibo, Wang, Lu, Volk, Andrew G., Birch, Noah W., Stoltz, Kristen L., Bartom, Elizabeth T., Marshall, Stacy A., Rendleman, Emily J., Nestler, Carson M., Shilati, Joseph, Schiltz, Gary E., Crispino, John D., Shilatifard, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317322/
https://www.ncbi.nlm.nih.gov/pubmed/30573454
http://dx.doi.org/10.1101/gad.319830.118

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