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Intraneural perineurioma: a retrospective study of 19 patients

Intraneural perineurioma is a benign neoplasm of peripheral nerve sheath with perineurial cell origin that typically affects teenagers and young adults and tends to result in a motor-predominant neuropathy. The aim of our study is to present the epidemiology, clinical presentation, way of diagnosis...

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Autores principales: Alkhaili, Jaber, Cambon-Binder, Adeline, Belkheyar, Zoubir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317392/
https://www.ncbi.nlm.nih.gov/pubmed/30637060
http://dx.doi.org/10.11604/pamj.2018.30.275.16072
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author Alkhaili, Jaber
Cambon-Binder, Adeline
Belkheyar, Zoubir
author_facet Alkhaili, Jaber
Cambon-Binder, Adeline
Belkheyar, Zoubir
author_sort Alkhaili, Jaber
collection PubMed
description Intraneural perineurioma is a benign neoplasm of peripheral nerve sheath with perineurial cell origin that typically affects teenagers and young adults and tends to result in a motor-predominant neuropathy. The aim of our study is to present the epidemiology, clinical presentation, way of diagnosis and management plan in a consecutive patient series. Ninteen patients diagnosed as having intraneural perineurioma were retrospectively chart reviewed. Diagnosis was done by MRI and/or biopsy with morphological, immunohistochemical staining study confirmation. Patients assessments included gender, age, symptoms, tumor localization, radiological aspect, management and pathological confirmation.Sex ratio was 10 males to 9 females with mean age of 31.2 (15-64). All the patients presented with motor deficit, ten with sensory deficit. Upper limb was involved in 11 cases (among them 4 lesions of brachial plexus), the lower limb in 8 cases. On magnetic resonance imaging, 16 patients showed a nerve enlargement whereas 5 presented with atypical fusiform tumor. Eighteen patients were operated for excision biopsy and/or palliative treatment for their motor deficit. Anatomopathological analysis confirmed the diagnosis in seventeen cases with a morphological pseudo-onion bulb shape and/or specific immunohistochemical assay. One patient had only palliative treatment without excision biopsy. Our data confirmed the equal penetration of intraneural perineurioma to both sex and affected limb. Because of the benignity of the tumor, the surgical treatment focused on optimizing the functional outcome. A prospective study with long term follow-up is required for this under-diagnosed tumor.
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spelling pubmed-63173922019-01-11 Intraneural perineurioma: a retrospective study of 19 patients Alkhaili, Jaber Cambon-Binder, Adeline Belkheyar, Zoubir Pan Afr Med J Case Series Intraneural perineurioma is a benign neoplasm of peripheral nerve sheath with perineurial cell origin that typically affects teenagers and young adults and tends to result in a motor-predominant neuropathy. The aim of our study is to present the epidemiology, clinical presentation, way of diagnosis and management plan in a consecutive patient series. Ninteen patients diagnosed as having intraneural perineurioma were retrospectively chart reviewed. Diagnosis was done by MRI and/or biopsy with morphological, immunohistochemical staining study confirmation. Patients assessments included gender, age, symptoms, tumor localization, radiological aspect, management and pathological confirmation.Sex ratio was 10 males to 9 females with mean age of 31.2 (15-64). All the patients presented with motor deficit, ten with sensory deficit. Upper limb was involved in 11 cases (among them 4 lesions of brachial plexus), the lower limb in 8 cases. On magnetic resonance imaging, 16 patients showed a nerve enlargement whereas 5 presented with atypical fusiform tumor. Eighteen patients were operated for excision biopsy and/or palliative treatment for their motor deficit. Anatomopathological analysis confirmed the diagnosis in seventeen cases with a morphological pseudo-onion bulb shape and/or specific immunohistochemical assay. One patient had only palliative treatment without excision biopsy. Our data confirmed the equal penetration of intraneural perineurioma to both sex and affected limb. Because of the benignity of the tumor, the surgical treatment focused on optimizing the functional outcome. A prospective study with long term follow-up is required for this under-diagnosed tumor. The African Field Epidemiology Network 2018-08-14 /pmc/articles/PMC6317392/ /pubmed/30637060 http://dx.doi.org/10.11604/pamj.2018.30.275.16072 Text en © Jaber Alkhaili et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Alkhaili, Jaber
Cambon-Binder, Adeline
Belkheyar, Zoubir
Intraneural perineurioma: a retrospective study of 19 patients
title Intraneural perineurioma: a retrospective study of 19 patients
title_full Intraneural perineurioma: a retrospective study of 19 patients
title_fullStr Intraneural perineurioma: a retrospective study of 19 patients
title_full_unstemmed Intraneural perineurioma: a retrospective study of 19 patients
title_short Intraneural perineurioma: a retrospective study of 19 patients
title_sort intraneural perineurioma: a retrospective study of 19 patients
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317392/
https://www.ncbi.nlm.nih.gov/pubmed/30637060
http://dx.doi.org/10.11604/pamj.2018.30.275.16072
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