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Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5′-Monophosphate Decarboxylase for Catalysis

[Image: see text] We report the results of a study of the catalytic role of a network of four interacting amino acid side chains at yeast orotidine 5′-monophosphate decarboxylase (ScOMPDC), by the stepwise replacement of all four side chains. The H-bond, which links the −CH(2)OH side chain of S154 f...

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Detalles Bibliográficos
Autores principales:	Reyes, Archie C., Plache, David C., Koudelka, Astrid P., Amyes, Tina L., Gerlt, John A., Richard, John P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317530/ https://www.ncbi.nlm.nih.gov/pubmed/30475611 http://dx.doi.org/10.1021/jacs.8b09609

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