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Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats

BACKGROUND: Whole body vibration training (WBV) is a new training program, which is safe and effective. It can be followed by the public. However, data on the safety and efficacy of vibration on myocardial ischemia reperfusion (IR) injury are lacking. OBJECTIVE: To examine the effect of WBV on the t...

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Autores principales: Shekarforoush, Shahnaz, Naghii, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia - SBC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317615/
https://www.ncbi.nlm.nih.gov/pubmed/30570068
http://dx.doi.org/10.5935/abc.20180252
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author Shekarforoush, Shahnaz
Naghii, Mohammad Reza
author_facet Shekarforoush, Shahnaz
Naghii, Mohammad Reza
author_sort Shekarforoush, Shahnaz
collection PubMed
description BACKGROUND: Whole body vibration training (WBV) is a new training program, which is safe and effective. It can be followed by the public. However, data on the safety and efficacy of vibration on myocardial ischemia reperfusion (IR) injury are lacking. OBJECTIVE: To examine the effect of WBV on the tolerance of the myocardium to acute IR injury in an experimental rat model. METHODS: Twenty-four male Wistar rats were divided into control and vibration groups. Vibration training consisted of vertical sinusoidal whole body vibration for 30 min per day, 6 days per week, for 1 or 3 weeks (WBV1 and WBV3 groups, respectively). All the rats were submitted to myocardial IR injury. Myocardial infarct size and ischemia-induced arrhythmias were assessed. Differences between variables were considered significant when p < 0.05. RESULTS: No differences were observed between the groups regarding the baseline hemodynamic parameters. Infarct size was smaller in the experimental group (control, 47 ± 2%; WBV1, 39 ± 2%; WBV3, 37 ± 2%; p < 0.05, vs. control). Vibration produced a significant decrease in the number and duration of ventricular tachycardia (VT) episodes compared to the control value. All ventricular fibrillation (VF) episodes in the vibration groups were self-limited, while 33% of the rats in the control group died due to irreversible VF (p = 0.02). CONCLUSION: The data showed that vibration training significantly increased cardiac tolerance to IR injury in rats, as evidenced by reduction in the infarct size and cardiac arrhythmias, and by facilitating spontaneous defibrillation.
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spelling pubmed-63176152019-01-07 Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats Shekarforoush, Shahnaz Naghii, Mohammad Reza Arq Bras Cardiol Original Article BACKGROUND: Whole body vibration training (WBV) is a new training program, which is safe and effective. It can be followed by the public. However, data on the safety and efficacy of vibration on myocardial ischemia reperfusion (IR) injury are lacking. OBJECTIVE: To examine the effect of WBV on the tolerance of the myocardium to acute IR injury in an experimental rat model. METHODS: Twenty-four male Wistar rats were divided into control and vibration groups. Vibration training consisted of vertical sinusoidal whole body vibration for 30 min per day, 6 days per week, for 1 or 3 weeks (WBV1 and WBV3 groups, respectively). All the rats were submitted to myocardial IR injury. Myocardial infarct size and ischemia-induced arrhythmias were assessed. Differences between variables were considered significant when p < 0.05. RESULTS: No differences were observed between the groups regarding the baseline hemodynamic parameters. Infarct size was smaller in the experimental group (control, 47 ± 2%; WBV1, 39 ± 2%; WBV3, 37 ± 2%; p < 0.05, vs. control). Vibration produced a significant decrease in the number and duration of ventricular tachycardia (VT) episodes compared to the control value. All ventricular fibrillation (VF) episodes in the vibration groups were self-limited, while 33% of the rats in the control group died due to irreversible VF (p = 0.02). CONCLUSION: The data showed that vibration training significantly increased cardiac tolerance to IR injury in rats, as evidenced by reduction in the infarct size and cardiac arrhythmias, and by facilitating spontaneous defibrillation. Sociedade Brasileira de Cardiologia - SBC 2019-01 /pmc/articles/PMC6317615/ /pubmed/30570068 http://dx.doi.org/10.5935/abc.20180252 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shekarforoush, Shahnaz
Naghii, Mohammad Reza
Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats
title Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats
title_full Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats
title_fullStr Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats
title_full_unstemmed Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats
title_short Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats
title_sort whole-body vibration training increases myocardial salvage against acute ischemia in adult male rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317615/
https://www.ncbi.nlm.nih.gov/pubmed/30570068
http://dx.doi.org/10.5935/abc.20180252
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