Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells

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Dynamin copolymerizes with cortactin to form a ring-like complex that bundles and stabilizes actin filaments. Actin bundle formation is crucial for generation of filopodia and lamellipodia, which guide migration, invasion, and metastasis of cancer cells. However, it is unknown how the dynamin-cortac...

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Detalles Bibliográficos
Autores principales: Abe, Tadashi, La, The Mon, Miyagaki, Yuuzi, Oya, Eri, Wei, Fan-Yan, Sumida, Kento, Fujise, Kenshiro, Takeda, Tetsuya, Tomizawa, Kazuhito, Takei, Kohji, Yamada, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317663/
https://www.ncbi.nlm.nih.gov/pubmed/30570111
http://dx.doi.org/10.3892/ijo.2018.4663

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