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Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation
The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA-approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, has shown limited efficacy in patients with medulloblastoma, du...
Autores principales: | Antonucci, Laura, Di Magno, Laura, D’Amico, Davide, Manni, Simona, Serrao, Silvia Maria, Di Pastena, Fiorella, Bordone, Rosa, Yurtsever, Zuleyha Nihan, Caimano, Miriam, Petroni, Marialaura, Giorgi, Alessandra, Schininà, Maria Eugenia, Yates, John r., Di Marcotullio, Lucia, De Smaele, Enrico, Checquolo, Saula, Capalbo, Carlo, Agostinelli, Enzo, Maroder, Marella, Coni, Sonia, Canettieri, Gianluca |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317670/ https://www.ncbi.nlm.nih.gov/pubmed/30483764 http://dx.doi.org/10.3892/ijo.2018.4638 |
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