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Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation

The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA-approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, has shown limited efficacy in patients with medulloblastoma, du...

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Detalles Bibliográficos
Autores principales: Antonucci, Laura, Di Magno, Laura, D’Amico, Davide, Manni, Simona, Serrao, Silvia Maria, Di Pastena, Fiorella, Bordone, Rosa, Yurtsever, Zuleyha Nihan, Caimano, Miriam, Petroni, Marialaura, Giorgi, Alessandra, Schininà, Maria Eugenia, Yates, John r., Di Marcotullio, Lucia, De Smaele, Enrico, Checquolo, Saula, Capalbo, Carlo, Agostinelli, Enzo, Maroder, Marella, Coni, Sonia, Canettieri, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317670/
https://www.ncbi.nlm.nih.gov/pubmed/30483764
http://dx.doi.org/10.3892/ijo.2018.4638

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