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Changes in QTc interval in long-term hemodialysis patients
BACKGROUND: Cardiovascular diseases, including sudden cardiac death (SCD), are the leading cause of death in hemodialysis (HD) patients. A prolonged QT interval on the electrocardiogram (ECG) is a risk factor for SCD in HD patients. This study investigated whether the heart rate-corrected QT (QTc) i...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317809/ https://www.ncbi.nlm.nih.gov/pubmed/30605455 http://dx.doi.org/10.1371/journal.pone.0209297 |
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author | Matsumoto, Yoshihiro Mori, Yasuo Kageyama, Shinji Arihara, Kazuo Sato, Hidemaro Nagata, Kijun Shimada, Yasushi Nojima, Yohichi Iguchi, Koichiro Sugiyama, Toshikazu |
author_facet | Matsumoto, Yoshihiro Mori, Yasuo Kageyama, Shinji Arihara, Kazuo Sato, Hidemaro Nagata, Kijun Shimada, Yasushi Nojima, Yohichi Iguchi, Koichiro Sugiyama, Toshikazu |
author_sort | Matsumoto, Yoshihiro |
collection | PubMed |
description | BACKGROUND: Cardiovascular diseases, including sudden cardiac death (SCD), are the leading cause of death in hemodialysis (HD) patients. A prolonged QT interval on the electrocardiogram (ECG) is a risk factor for SCD in HD patients. This study investigated whether the heart rate-corrected QT (QTc) interval becomes prolonged along with dialysis vintage. METHODS: A total of 102 HD patients were retrospectively studied. Their ECG data were analyzed at 1, 4, and 7 years after HD initiation. The control group comprised 68 age-matched individuals who had normal renal function and two available ECG reports at an interval of more than 4 years. QTc was measured according to the Bazett formula. The association between QTc interval and dialysis vintage was studied. Additionally, clinically relevant variables related to QTc duration at 1 year after HD initiation were assessed. RESULTS: Average QTc interval at 4 and 7 years after HD initiation was significantly longer than that at 1 year after HD initiation (443, 445, and 437 ms) (p<0.05). On the other hand, QTc interval in the control group was 425 ms in the first year and 426 ms after an average of 6 years. They had no significant differences, although they were much shorter than that in HD patients. Multivariate regression analysis of baseline variables revealed that the corrected calcium levels (p = 0.041) and diabetes (p = 0.043) were independently associated with longer QTc interval. CONCLUSIONS: The QTc interval at 1 year after HD initiation was longer than in the control subjects and was prolonged over several years of HD treatment. Providing clinical management with a focus on QTc interval may be helpful for reducing the incidence of SCD in HD patients. |
format | Online Article Text |
id | pubmed-6317809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63178092019-01-19 Changes in QTc interval in long-term hemodialysis patients Matsumoto, Yoshihiro Mori, Yasuo Kageyama, Shinji Arihara, Kazuo Sato, Hidemaro Nagata, Kijun Shimada, Yasushi Nojima, Yohichi Iguchi, Koichiro Sugiyama, Toshikazu PLoS One Research Article BACKGROUND: Cardiovascular diseases, including sudden cardiac death (SCD), are the leading cause of death in hemodialysis (HD) patients. A prolonged QT interval on the electrocardiogram (ECG) is a risk factor for SCD in HD patients. This study investigated whether the heart rate-corrected QT (QTc) interval becomes prolonged along with dialysis vintage. METHODS: A total of 102 HD patients were retrospectively studied. Their ECG data were analyzed at 1, 4, and 7 years after HD initiation. The control group comprised 68 age-matched individuals who had normal renal function and two available ECG reports at an interval of more than 4 years. QTc was measured according to the Bazett formula. The association between QTc interval and dialysis vintage was studied. Additionally, clinically relevant variables related to QTc duration at 1 year after HD initiation were assessed. RESULTS: Average QTc interval at 4 and 7 years after HD initiation was significantly longer than that at 1 year after HD initiation (443, 445, and 437 ms) (p<0.05). On the other hand, QTc interval in the control group was 425 ms in the first year and 426 ms after an average of 6 years. They had no significant differences, although they were much shorter than that in HD patients. Multivariate regression analysis of baseline variables revealed that the corrected calcium levels (p = 0.041) and diabetes (p = 0.043) were independently associated with longer QTc interval. CONCLUSIONS: The QTc interval at 1 year after HD initiation was longer than in the control subjects and was prolonged over several years of HD treatment. Providing clinical management with a focus on QTc interval may be helpful for reducing the incidence of SCD in HD patients. Public Library of Science 2019-01-03 /pmc/articles/PMC6317809/ /pubmed/30605455 http://dx.doi.org/10.1371/journal.pone.0209297 Text en © 2019 Matsumoto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Matsumoto, Yoshihiro Mori, Yasuo Kageyama, Shinji Arihara, Kazuo Sato, Hidemaro Nagata, Kijun Shimada, Yasushi Nojima, Yohichi Iguchi, Koichiro Sugiyama, Toshikazu Changes in QTc interval in long-term hemodialysis patients |
title | Changes in QTc interval in long-term hemodialysis patients |
title_full | Changes in QTc interval in long-term hemodialysis patients |
title_fullStr | Changes in QTc interval in long-term hemodialysis patients |
title_full_unstemmed | Changes in QTc interval in long-term hemodialysis patients |
title_short | Changes in QTc interval in long-term hemodialysis patients |
title_sort | changes in qtc interval in long-term hemodialysis patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317809/ https://www.ncbi.nlm.nih.gov/pubmed/30605455 http://dx.doi.org/10.1371/journal.pone.0209297 |
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