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Changes in QTc interval in long-term hemodialysis patients

BACKGROUND: Cardiovascular diseases, including sudden cardiac death (SCD), are the leading cause of death in hemodialysis (HD) patients. A prolonged QT interval on the electrocardiogram (ECG) is a risk factor for SCD in HD patients. This study investigated whether the heart rate-corrected QT (QTc) i...

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Autores principales: Matsumoto, Yoshihiro, Mori, Yasuo, Kageyama, Shinji, Arihara, Kazuo, Sato, Hidemaro, Nagata, Kijun, Shimada, Yasushi, Nojima, Yohichi, Iguchi, Koichiro, Sugiyama, Toshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317809/
https://www.ncbi.nlm.nih.gov/pubmed/30605455
http://dx.doi.org/10.1371/journal.pone.0209297
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author Matsumoto, Yoshihiro
Mori, Yasuo
Kageyama, Shinji
Arihara, Kazuo
Sato, Hidemaro
Nagata, Kijun
Shimada, Yasushi
Nojima, Yohichi
Iguchi, Koichiro
Sugiyama, Toshikazu
author_facet Matsumoto, Yoshihiro
Mori, Yasuo
Kageyama, Shinji
Arihara, Kazuo
Sato, Hidemaro
Nagata, Kijun
Shimada, Yasushi
Nojima, Yohichi
Iguchi, Koichiro
Sugiyama, Toshikazu
author_sort Matsumoto, Yoshihiro
collection PubMed
description BACKGROUND: Cardiovascular diseases, including sudden cardiac death (SCD), are the leading cause of death in hemodialysis (HD) patients. A prolonged QT interval on the electrocardiogram (ECG) is a risk factor for SCD in HD patients. This study investigated whether the heart rate-corrected QT (QTc) interval becomes prolonged along with dialysis vintage. METHODS: A total of 102 HD patients were retrospectively studied. Their ECG data were analyzed at 1, 4, and 7 years after HD initiation. The control group comprised 68 age-matched individuals who had normal renal function and two available ECG reports at an interval of more than 4 years. QTc was measured according to the Bazett formula. The association between QTc interval and dialysis vintage was studied. Additionally, clinically relevant variables related to QTc duration at 1 year after HD initiation were assessed. RESULTS: Average QTc interval at 4 and 7 years after HD initiation was significantly longer than that at 1 year after HD initiation (443, 445, and 437 ms) (p<0.05). On the other hand, QTc interval in the control group was 425 ms in the first year and 426 ms after an average of 6 years. They had no significant differences, although they were much shorter than that in HD patients. Multivariate regression analysis of baseline variables revealed that the corrected calcium levels (p = 0.041) and diabetes (p = 0.043) were independently associated with longer QTc interval. CONCLUSIONS: The QTc interval at 1 year after HD initiation was longer than in the control subjects and was prolonged over several years of HD treatment. Providing clinical management with a focus on QTc interval may be helpful for reducing the incidence of SCD in HD patients.
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spelling pubmed-63178092019-01-19 Changes in QTc interval in long-term hemodialysis patients Matsumoto, Yoshihiro Mori, Yasuo Kageyama, Shinji Arihara, Kazuo Sato, Hidemaro Nagata, Kijun Shimada, Yasushi Nojima, Yohichi Iguchi, Koichiro Sugiyama, Toshikazu PLoS One Research Article BACKGROUND: Cardiovascular diseases, including sudden cardiac death (SCD), are the leading cause of death in hemodialysis (HD) patients. A prolonged QT interval on the electrocardiogram (ECG) is a risk factor for SCD in HD patients. This study investigated whether the heart rate-corrected QT (QTc) interval becomes prolonged along with dialysis vintage. METHODS: A total of 102 HD patients were retrospectively studied. Their ECG data were analyzed at 1, 4, and 7 years after HD initiation. The control group comprised 68 age-matched individuals who had normal renal function and two available ECG reports at an interval of more than 4 years. QTc was measured according to the Bazett formula. The association between QTc interval and dialysis vintage was studied. Additionally, clinically relevant variables related to QTc duration at 1 year after HD initiation were assessed. RESULTS: Average QTc interval at 4 and 7 years after HD initiation was significantly longer than that at 1 year after HD initiation (443, 445, and 437 ms) (p<0.05). On the other hand, QTc interval in the control group was 425 ms in the first year and 426 ms after an average of 6 years. They had no significant differences, although they were much shorter than that in HD patients. Multivariate regression analysis of baseline variables revealed that the corrected calcium levels (p = 0.041) and diabetes (p = 0.043) were independently associated with longer QTc interval. CONCLUSIONS: The QTc interval at 1 year after HD initiation was longer than in the control subjects and was prolonged over several years of HD treatment. Providing clinical management with a focus on QTc interval may be helpful for reducing the incidence of SCD in HD patients. Public Library of Science 2019-01-03 /pmc/articles/PMC6317809/ /pubmed/30605455 http://dx.doi.org/10.1371/journal.pone.0209297 Text en © 2019 Matsumoto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Matsumoto, Yoshihiro
Mori, Yasuo
Kageyama, Shinji
Arihara, Kazuo
Sato, Hidemaro
Nagata, Kijun
Shimada, Yasushi
Nojima, Yohichi
Iguchi, Koichiro
Sugiyama, Toshikazu
Changes in QTc interval in long-term hemodialysis patients
title Changes in QTc interval in long-term hemodialysis patients
title_full Changes in QTc interval in long-term hemodialysis patients
title_fullStr Changes in QTc interval in long-term hemodialysis patients
title_full_unstemmed Changes in QTc interval in long-term hemodialysis patients
title_short Changes in QTc interval in long-term hemodialysis patients
title_sort changes in qtc interval in long-term hemodialysis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317809/
https://www.ncbi.nlm.nih.gov/pubmed/30605455
http://dx.doi.org/10.1371/journal.pone.0209297
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