Elevated α-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation

We report a rare case of marked elevation of α-fetoprotein in the absence of hepatocellular carcinoma caused by a relapse of hepatitis C virus (HCV) infection. A 58-year-old man underwent liver transplantation to treat hepatocellular carcinoma caused by HCV-related liver cirrhosis. The HCV was of ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Kogiso, Tomomi, Sagawa, Takaomi, Kotera, Yoshihito, Egawa, Hiroto, Yamamoto, Masakazu, Tokushige, Katsutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317834/
https://www.ncbi.nlm.nih.gov/pubmed/30643846
http://dx.doi.org/10.14309/crj.2018.103
_version_ 1783384791433871360
author Kogiso, Tomomi
Sagawa, Takaomi
Kotera, Yoshihito
Egawa, Hiroto
Yamamoto, Masakazu
Tokushige, Katsutoshi
author_facet Kogiso, Tomomi
Sagawa, Takaomi
Kotera, Yoshihito
Egawa, Hiroto
Yamamoto, Masakazu
Tokushige, Katsutoshi
author_sort Kogiso, Tomomi
collection PubMed
description We report a rare case of marked elevation of α-fetoprotein in the absence of hepatocellular carcinoma caused by a relapse of hepatitis C virus (HCV) infection. A 58-year-old man underwent liver transplantation to treat hepatocellular carcinoma caused by HCV-related liver cirrhosis. The HCV was of genotype 2a, and the ribonucleic acid titer was >8.0 log IU/mL. Direct-acting antiviral drugs were prescribed for 12 weeks; however, the HCV infection relapsed after treatment had ended, and α-fetoprotein levels increased to 8,981 ng/mL. Imaging did not reveal any malignancies. The patient initiated interferon therapy, at which time AFP levels decreased, and the HCV was successfully cleared.
format Online
Article
Text
id pubmed-6317834
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American College of Gastroenterology
record_format MEDLINE/PubMed
spelling pubmed-63178342019-01-14 Elevated α-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation Kogiso, Tomomi Sagawa, Takaomi Kotera, Yoshihito Egawa, Hiroto Yamamoto, Masakazu Tokushige, Katsutoshi ACG Case Rep J Case Report We report a rare case of marked elevation of α-fetoprotein in the absence of hepatocellular carcinoma caused by a relapse of hepatitis C virus (HCV) infection. A 58-year-old man underwent liver transplantation to treat hepatocellular carcinoma caused by HCV-related liver cirrhosis. The HCV was of genotype 2a, and the ribonucleic acid titer was >8.0 log IU/mL. Direct-acting antiviral drugs were prescribed for 12 weeks; however, the HCV infection relapsed after treatment had ended, and α-fetoprotein levels increased to 8,981 ng/mL. Imaging did not reveal any malignancies. The patient initiated interferon therapy, at which time AFP levels decreased, and the HCV was successfully cleared. American College of Gastroenterology 2018-12-19 /pmc/articles/PMC6317834/ /pubmed/30643846 http://dx.doi.org/10.14309/crj.2018.103 Text en Copyright © Kogiso et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Kogiso, Tomomi
Sagawa, Takaomi
Kotera, Yoshihito
Egawa, Hiroto
Yamamoto, Masakazu
Tokushige, Katsutoshi
Elevated α-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation
title Elevated α-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation
title_full Elevated α-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation
title_fullStr Elevated α-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation
title_full_unstemmed Elevated α-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation
title_short Elevated α-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation
title_sort elevated α-fetoprotein in the absence of carcinoma caused by relapse of hepatitis c viral infection after liver transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317834/
https://www.ncbi.nlm.nih.gov/pubmed/30643846
http://dx.doi.org/10.14309/crj.2018.103
work_keys_str_mv AT kogisotomomi elevatedafetoproteinintheabsenceofcarcinomacausedbyrelapseofhepatitiscviralinfectionafterlivertransplantation
AT sagawatakaomi elevatedafetoproteinintheabsenceofcarcinomacausedbyrelapseofhepatitiscviralinfectionafterlivertransplantation
AT koterayoshihito elevatedafetoproteinintheabsenceofcarcinomacausedbyrelapseofhepatitiscviralinfectionafterlivertransplantation
AT egawahiroto elevatedafetoproteinintheabsenceofcarcinomacausedbyrelapseofhepatitiscviralinfectionafterlivertransplantation
AT yamamotomasakazu elevatedafetoproteinintheabsenceofcarcinomacausedbyrelapseofhepatitiscviralinfectionafterlivertransplantation
AT tokushigekatsutoshi elevatedafetoproteinintheabsenceofcarcinomacausedbyrelapseofhepatitiscviralinfectionafterlivertransplantation

Ejemplares similares