Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer’s disease (AD). However, mechanisms linking blood-brain barrier (BBB) disruption with neurodege...

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Detalles Bibliográficos
Autores principales: Ryu, Jae Kyu, Rafalski, Victoria A., Meyer-Franke, Anke, Adams, Ryan A., Poda, Suresh B., Coronado, Pamela E. Rios, Pedersen, Lars Østergaard, Menon, Veena, Baeten, Kim M., Sikorski, Shoana L., Bedard, Catherine, Hanspers, Kristina, Bardehle, Sophia, Mendiola, Andrew S., Davalos, Dimitrios, Machado, Michael R., Chan, Justin P., Plastira, Ioanna, Petersen, Mark A., Pfaff, Samuel J., Ang, Kenny K., Hallenbeck, Kenneth K., Syme, Catriona, Hakozaki, Hiroyuki, Ellisman, Mark H., Swanson, Raymond A., Zamvil, Scott S., Arkin, Michelle R., Zorn, Stevin H., Pico, Alexander R., Mucke, Lennart, Freedman, Stephen B., Stavenhagen, Jeffrey B., Nelson, Robert B., Akassoglou, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317891/
https://www.ncbi.nlm.nih.gov/pubmed/30323343
http://dx.doi.org/10.1038/s41590-018-0232-x

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