Cargando…
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ
Crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) have revealed overlapping binding modes for synthetic and natural/endogenous ligands, indicating competition for the orthosteric pocket. Here we show that cobinding of a synthetic ligand to the orthosteric pocket can push...
Autores principales: | Shang, Jinsai, Brust, Richard, Mosure, Sarah A, Bass, Jared, Munoz-Tello, Paola, Lin, Hua, Hughes, Travis S, Tang, Miru, Ge, Qingfeng, Kamenekca, Theodore M, Kojetin, Douglas J |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317912/ https://www.ncbi.nlm.nih.gov/pubmed/30575522 http://dx.doi.org/10.7554/eLife.43320 |
Ejemplares similares
-
A molecular switch regulating transcriptional repression and activation of PPARγ
por: Shang, Jinsai, et al.
Publicado: (2020) -
Molecular basis of ligand-dependent Nurr1-RXRα activation
por: Yu, Xiaoyu, et al.
Publicado: (2023) -
A structural mechanism for directing corepressor-selective inverse agonism of PPARγ
por: Brust, Richard, et al.
Publicado: (2018) -
HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists
por: Strutzenberg, Timothy S, et al.
Publicado: (2019) -
Correction: HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists
por: Strutzenberg, Timothy S, et al.
Publicado: (2019)